ArticleBiophysical journal2005
Desmin filaments influence myofilament spacing and lateral compliance of slow skeletal muscle fibers.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- LIM-Nebulette Reinforces Podocyte Structural Integrity by Linking Actin and Vimentin Filaments.Journal of the American Society of Nephrology : JASN · 2020Article
- Striated myocyte structural integrity: Automated analysis of sarcomeric z-discs.PLoS computational biology · 2020Article
- Deficiency of the intermediate filament synemin reduces bone mass in vivo.American journal of physiology. Cell physiology · 2016Article
- Knockdown of desmin in zebrafish larvae affects interfilament spacing and mechanical properties of skeletal muscle.The Journal of general physiology · 2013Article
- Increased desmin expression in hindlimb muscles of aging rats.Journal of cachexia, sarcopenia and muscle · 2011Article
- A mathematical model of muscle containing heterogeneous half-sarcomeres exhibits residual force enhancement.PLoS computational biology · 2011Article
- Physiology, structure, and susceptibility to injury of skeletal muscle in mice lacking keratin 19-based and desmin-based intermediate filaments.American journal of physiology. Cell physiology · 2011Article
- Interactions between connected half-sarcomeres produce emergent mechanical behavior in a mathematical model of muscle.PLoS computational biology · 2009Article
- Lens intermediate filaments.Experimental eye research · 2009Review
- Effects of electrical stimulation in C2C12 muscle constructs.Journal of tissue engineering and regenerative medicine · 2008Article
- Intermediate filaments in smooth muscle.American journal of physiology. Cell physiology · 2008Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intermediate filaments composed of desmin interlink Z-disks and sarcolemma in skeletal muscle. Depletion of desmin results in lower active stress of smooth, cardiac, and skeletal muscles. Structural functions of intermediate filaments in fast (psoas) and slow (soleus) skeletal muscle were examined using x-ray diffraction on permeabilized muscle from desmin-deficient mice (Des-/-) and controls (Des+/+). To examine lateral compliance of sarcomeres and cells, filament distances and fiber width were measured during osmotic compression with dextran. Equatorial spacing (x-ray diffraction) of contractile filaments was wider in soleus Des-/- muscle compared to Des+/+, showing that desmin is important for maintaining lattice structure. Osmotic lattice compression was similar in Des-/- and Des+/+. In width measurements of single fibers and bundles, Des-/- soleus were more compressed by dextran compared to Des+/+, showing that intermediate filaments contribute to whole-cell compliance. For psoas fibers, both filament distance and cell compliance were similar in Des-/- and Des+/+. We conclude that desmin is important for stabilizing sarcomeres and maintaining cell compliance in slow skeletal muscle. Wider filament spacing in Des-/- soleus cannot, however, explain the lower active stress, but might influence resistance to stretch, possibly minimizing stretch-induced cell injury.
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