ArticleBiophysical journal2005
Effect of membrane characteristics on phase separation and domain formation in cholesterol-lipid mixtures.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Amyloid-β peptide dimers undergo a random coil to β-sheet transition in the aqueous phase but not at the neuronal membrane.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Structure-based prediction of drug distribution across the headgroup and core strata of a phospholipid bilayer using surrogate phases.Molecular pharmaceutics · 2014Article
- Limited perturbation of a DPPC bilayer by fluorescent lipid probes: a molecular dynamics study.The journal of physical chemistry. B · 2013Article
- Saturation with cholesterol increases vertical order and smoothes the surface of the phosphatidylcholine bilayer: a molecular simulation study.Biochimica et biophysica acta · 2012Article
- Using spin-label electron paramagnetic resonance (EPR) to discriminate and characterize the cholesterol bilayer domain.Chemistry and physics of lipids · 2011Article
- Instability of cholesterol clusters in lipid bilayers and the cholesterol's Umbrella effect.The journal of physical chemistry. B · 2010Article
- Phase behavior of lipid monolayers containing DPPC and cholesterol analogs.Biophysical journal · 2006Article
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Authors and funding
2 authors.
Funding
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Abstract
We examine, using an analytical mean-field model, the distribution of cholesterol in a lipid bilayer. The model accounts for the perturbation of lipid packing induced by the embedded cholesterol, in a manner similar to that of transmembrane proteins. We find that the membrane-induced interactions between embedded cholesterol molecules vary as a function of the cholesterol content. Thus, the effective lipid-cholesterol interaction is concentration-dependent. Moreover, it transitions from repulsive to attractive to repulsive as the cholesterol content increases. As the concentration of cholesterol in the bilayer exceeds a critical value, phase separation occurs. The coexistence between cholesterol-rich and cholesterol-poor domains is universal for any bilayer parameters, although the composition of the cholesterol-rich phase varies as a function of the lipid properties. Although we do not assume specific cholesterol-lipid interactions or the formation of a lipid-cholesterol cluster, we find that the composition of the cholesterol-rich domains is constant, independent of the cholesterol content in the bilayer.
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