Evidence map›Paper›PMID 15540159›Full record

ReviewAmerican journal of human genetics2005

Prospects for admixture mapping of complex traits.

Paul M McKeigue

Abstract readComparative StudyReview
In one paragraph

Review in American journal of human genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Human genetic admixture.PLoS genetics · 2021
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
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  15. Review
  16. Article
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  18. Red blood cell alloimmunization in sickle cell disease: listen to your ancestors.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2014
    Review
  19. Article
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Paul M McKeigueConway Institute, University College Dublin, Belfield, Dublin 4, Ireland. paul.mckeigue@ucd.ie

Funding

GENES UNDERLYING ETHNIC DIFFERENCES IN DISEASE RISKR01MH060343 · NIMH · U OF L LONDON SCH/HYGIENE &TROPICAL MED · PI MCKEIGUE, PAUL M · 2000 to 2002
$350k
NIMH NIH HHS MH 60343
6 · The paper itself

Abstract

Admixture mapping extends to human populations the principles that underlie linkage analysis of an experimental cross. For detecting genes that contribute to ethnic variation in disease risk, admixture mapping has greater statistical power than family-linkage studies. In comparison with association studies, admixture mapping requires far fewer markers to search the genome and is less affected by allelic heterogeneity. Statistical-analysis programs for admixture mapping are now available, and a genomewide panel of markers for admixture mapping in populations formed by West African-European admixture has been assembled. Some of the remaining technical challenges include the ability to ensure that the statistical methods are robust and to develop marker panels for other admixed populations. Where admixed populations and panels of markers informative for ancestry are available, admixture mapping can be applied to localize genes that contribute to ethnic variation in any measurable trait.

Indexed as

Black PeopleChromosome MappingGene DosageGenetic HeterogeneityGenetic LinkageGenetic MarkersGenetic Predisposition to DiseaseHumansModels, GeneticWhite PeopleGenetic Markers

Identifiers

PMID15540159
PMCPMC1196412

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.