ArticleAmerican journal of human genetics2005
Mathematical assumptions versus biological reality: myths in affected sib pair linkage analysis.
Article in American journal of human genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Causal models for investigating complex genetic disease: II. what causal models can tell us about penetrance for additive, heterogeneity, and multiplicative two-locus models.Human heredity · 2011Article
- Some capabilities for model-based and model-free linkage analysis using the program package S.A.G.E. (Statistical Analysis for Genetic Epidemiology).Human heredity · 2011Article
- Causal models for investigating complex disease: I. A primer.Human heredity · 2011Article
- Program update and novel use of the DESPAIR program to design a genome-wide linkage study using relative pairs.Human heredity · 2010Article
- Finding genes underlying human disease.Clinical genetics · 2009Review
- Detecting selection-induced departures from Hardy-Weinberg proportions.Genetics, selection, evolution : GSE · 2009Article
- Influence of genotyping error in linkage mapping for complex traits--an analytic study.BMC genetics · 2008Article
- Consistently replicating locus linked to migraine on 10q22-q23.American journal of human genetics · 2008Article
- Identification of susceptibility genes for cancer in a genome-wide scan: results from the colon neoplasia sibling study.American journal of human genetics · 2008Article
- Haseman-Elston regression in ascertained samples: importance of dependent variable and mean correction factor selection.Human heredity · 2008Article
- Comparison of affected sibling-pair linkage methods to identify gene x gene interaction in GAW15 simulated data.BMC proceedings · 2007Article
- Genetic characterization and fine mapping of susceptibility loci for sarcoidosis in African Americans on chromosome 5.Human genetics · 2006Article
- The affected-/discordant-sib-pair design can guarantee validity of multipoint model-free linkage analysis of incomplete pedigrees when there is marker-marker disequilibrium.American journal of human genetics · 2006Article
- Variance calculations for identity-by-descent estimation.American journal of human genetics · 2006Article
- Interval estimation of disease loci: development and applications of new linkage methods.BMC genetics · 2005Article
- Linkage analysis of alcohol dependence using both affected and discordant sib pairs.BMC genetics · 2005Article
- Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q.American journal of human genetics · 2005Article
- Genome-wide search for sarcoidosis susceptibility genes in African Americans.Genes and immunity · 2005Article
- Genomewide significant linkage to migrainous headache on chromosome 5q21.American journal of human genetics · 2005Article
- Population genetic approaches to neurological disease: Parkinson's disease as an example.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2005Review
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3 authors.
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Abstract
Affected sib pair (ASP) analysis has become common ever since it was shown that, under very specific assumptions, ASPs afford a powerful design for linkage analysis. In 2003, Vieland and Huang, on the basis of a "fundamental heterogeneity equation," proved that heterogeneity and epistasis are confounded in ASP linkage analysis. A much more serious limitation of ASP linkage analysis is the implicit assumption that randomly sampled sib pairs share half their alleles identical by descent at any locus, whereas a critical assumption underlying Vieland and Huang's proof is that of joint Hardy-Weinberg equilibrium proportions at two trait loci. These are considered as examples of mathematical assumptions that may not always reflect biological reality. More-robust sib-pair designs and appropriate methods for their analysis have long been available.
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