ArticleThe Plant cell2004
The essential basic helix-loop-helix protein FIT1 is required for the iron deficiency response.
Article in The Plant cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 323 papers.
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Who cites it
323 citing papers in PubMed, 792 citations in OpenAlex.
- TurboID-based proteomic profiling reveals proxitome of the IRT1 metal transporter and new insight into IRT1 endocytosis.The New phytologist · 2026Article
- CARK3-mediated phosphorylation of bHLH106 inhibits iron uptake by repressing the expression of IRT1 in Arabidopsis.Plant communications · 2026Article
- MPK3-mediated phosphorylation inactivates MYB4 to promote FIT-dependent iron acquisition.EMBO reports · 2026Article
- Cross-Species Plasticity and Divergence Under Alkaline Soil Signature Conditions Differentiating PYE From FIT Target Transcripts in the Arabidopsis thaliana Ferrome.Plant, cell & environment · 2026Article
- Systemic acquired resistance signaling molecule N-hydroxypipecolic acid is involved in Age-related resistance in Arabidopsis thaliana.Plant physiology · 2026Article
- Accelerating iron biofortification in millets: progress, challenges, and future prospects.Planta · 2026Review
- They look like gold: CITF1 and FIT interaction mediate cross-talk between iron and copper.The Plant cell · 2026Article
- CRISPR/Cas9 Editing of the Wheat Iron Sensor TaHRZ1 Confirms Its Conserved Role in Iron Homeostasis and Allocation in Grains.Plant, cell & environment · 2026Article
- From the Cosmos to the Cell: The Central Role of Iron in the Chemistry and Evolution of Life.International journal of molecular sciences · 2026Review
- Hypoxic and Fe-Responses are Regulated by the ERFVII Factors and the PCO Branch of the N-Degron Pathway According to Iron Availability.Plant, cell & environment · 2026Article
- CITF1 interacts with FIT and regulates copper-iron crosstalk in Arabidopsis.The Plant cell · 2026Article
- The Arabidopsis NPF7.2 mediates coumarin uptake for root iron acquisition.The New phytologist · 2026Article
- Nitric oxide donor sodium nitroprusside enhances iron deficiency tolerance in M7 apple plants through coordinated regulation of Fe acquisition genes and physiological responses.Scientific reports · 2026Article
- Metabolic analysis of MYB30 that regulates iron deficiency stress inFrontiers in plant science · 2026Article
- Integrating microbial siderophores into concepts of plant iron nutrition.Nature plants · 2026Review
- Professor Jeeyon Jeong (1977-2024), an insightful scholar and generous mentor.Frontiers in plant science · 2026Article
- Molecular Mechanism by Which the BrFIT2-BrbHLH-BrIRT1 Module Synergistically Regulates Iron Absorption in Brassica rapa ssp. Pekinensis.Plant biotechnology journal · 2025Article
- Iron deficiency changes regulatory mechanisms governing sieve element cell differentiation.Nature communications · 2025Article
- Age-dependent differential iron deficiency responses of rosette leaves during reproductive stages in Arabidopsis thaliana.Journal of experimental botany · 2025Article
- Physiological, Biochemical, and Transcriptomic Responses to Iron Deficiency in Two Potato Varieties.Plants (Basel, Switzerland) · 2025Article
263 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regulation of iron uptake is critical for plant survival. Although the activities responsible for reduction and transport of iron at the plant root surface have been described, the genes controlling these activities are largely unknown. We report the identification of the essential gene Fe-deficiency Induced Transcription Factor 1 (FIT1), which encodes a putative transcription factor that regulates iron uptake responses in Arabidopsis thaliana. Like the Fe(III) chelate reductase FRO2 and high affinity Fe(II) transporter IRT1, FIT1 mRNA is detected in the outer cell layers of the root and accumulates in response to iron deficiency. fit1 mutant plants are chlorotic and die as seedlings but can be rescued by the addition of supplemental iron, pointing to a defect in iron uptake. fit1 mutant plants accumulate less iron than wild-type plants in root and shoot tissues. Microarray analysis shows that expression of many (72 of 179) iron-regulated genes is dependent on FIT1. We demonstrate that FIT1 regulates FRO2 at the level of mRNA accumulation and IRT1 at the level of protein accumulation. We propose a new model for iron uptake in Arabidopsis where FRO2 and IRT1 are differentially regulated by FIT1.
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