ArticleProceedings of the National Academy of Sciences of the United States of America2004
Mechanotransduction and strain amplification in osteocyte cell processes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers.
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Who cites it
143 citing papers in PubMed, 490 citations in OpenAlex.
- Children with unilateral spastic cerebral palsy have smaller and weaker tibias in the spastic limb compared to the non-spastic limb.Bone reports · 2026Article
- Intravital Depletion of Cholesterol Reduces Membrane Dynamics and Increases Mechanosensitivity in Osteocytes In Vivo.bioRxiv : the preprint server for biology · 2026Article
- Mesenchymal stem cells differentiate dynamic from static load through variable regulation of the Hippo pathway.Journal of biomechanics · 2026Article
- Harnessing Advances in Bone Tissue Engineering for Design of Bone-on-Chip Systems.Advanced healthcare materials · 2026Review
- Piezo1-mediated mechanotransduction controls osteocyte maturation and dendrite development via a YAP-CCN-Src signaling axis.Nature communications · 2025Article
- Real-time visualization and modulation of endocytic dynamics in osteocytes in vivo.Scientific reports · 2025Article
- Predicting cortical bone resorption in the mouse tibia under disuse conditions caused by transient muscle paralysis.Scientific reports · 2025Article
- Structure, Mechanics, and Mechanobiology of Fibrocartilage Pericellular Matrix Mediated by Type V Collagen.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Osteocytes function as biomechanical signaling hubs bridging mechanical stress sensing and systemic adaptation.Frontiers in physiology · 2025Review
- Inflammation and mechanical force-induced bone remodeling.Periodontology 2000 · 2024Review
- Aging decreases osteocyte peri-lacunar-canalicular system turnover in female C57BL/6JN mice.Bone · 2024Article
- The multi-faceted nature of age-associated osteoporosis.Bone reports · 2024Review
- Computational modeling based on confocal imaging predicts changes in osteocyte and dendrite shear stress due to canalicular loss with aging.Biomechanics and modeling in mechanobiology · 2024Article
- Osteocyte-mediated mechanical response controls osteoblast differentiation and function.Frontiers in physiology · 2024Review
- Implant-supported prosthesis under progressive loading protocol stimulates alveolar bone growth in patients with severe alveolar bone atrophy. Retrospective case series.Frontiers in dental medicine · 2024Article
- Influence of Osteocyte Lacunar-Canalicular Morphology and Network Architecture on Osteocyte Mechanosensitivity.Current osteoporosis reports · 2023Review
- The regulation and functions of the matricellular CCN proteins induced by shear stress.Journal of cell communication and signaling · 2023Review
- The myosin and RhoGAP MYO9B influences osteocyte dendrite growth and responses to mechanical stimuli.Frontiers in bioengineering and biotechnology · 2023Article
- Clinical parameters correlated with the psoas muscle index in Japanese individuals with type 2 diabetes mellitus.Diabetology international · 2023Article
- Gabapentin Disrupts Binding of Perlecan to the αBiomolecules · 2022Article
83 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
A paradox in bone tissue is that tissue-level strains due to animal and human locomotion are too small to initiate intracellular chemical responses directly. A model recently was proposed to resolve this paradox, which predicts that the fluid flow through the pericellular matrix in the lacunar-canalicular porosity due to mechanical loading can induce strains in the actin filament bundles of the cytoskeleton that are more than an order of magnitude larger than tissue level strains. In this study, we greatly refine this model by using the latest ultrastructural data for the cell process cytoskeleton, the tethering elements that attach the process to the canalicular wall and their finite flexural rigidity EI. We construct a much more realistic 3D model for the osteocyte process and then use large-deformation "elastica" theory for finite EI to predict the deformed shape of the tethering elements and the hoop strain on the central actin bundle. Our model predicts a cell process that is 3 times stiffer than in a previous study but hoop strain of >0.5% for tissue-level strains of >1,000 microstrain at 1 Hz and >250 microstrain at frequencies >10 Hz. We propose that this strain-amplification model provides a more likely hypothesis for the excitation of osteocytes than the previously proposed fluid-shear hypothesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.