ArticleAnnals of the rheumatic diseases2005
CARD15 gene polymorphisms in patients with spondyloarthropathies identify a specific phenotype previously related to Crohn's disease.
Article in Annals of the rheumatic diseases, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Importance of intestinal microenvironment in development of arthritis. A systematic review.Immunologic research · 2015Pooled it
- The potential role of the gut microbiota in the development of autoantibodies associated with Spondyloarthritis: a narrative review.BMC immunology · 2026Review
- Genome-wide cross-trait analysis reveals shared genetic architecture between inflammatory bowel disease and ankylosing spondylitis.Scientific reports · 2026Article
- Biologic Treatment Modification Efficacy in Concurrent Inflammatory Bowel Disease and Ankylosing Spondylitis: A Retrospective Cohort Study at a Single Tertiary Center.Journal of clinical medicine · 2023Article
- Human Leukocyte Antigen B27-Negative Axial Spondyloarthritis: What Do We Know?ACR open rheumatology · 2023Review
- [Update: enterogenic spondylarthritis].Zeitschrift fur Rheumatologie · 2021Article
- Ankylosing spondylitis: an autoimmune or autoinflammatory disease?Nature reviews. Rheumatology · 2021Review
- Revisiting the gut-joint axis: links between gut inflammation and spondyloarthritis.Nature reviews. Rheumatology · 2020Review
- Bidirectional Causal Associations Between Inflammatory Bowel Disease and Ankylosing Spondylitis: A Two-Sample Mendelian Randomization Analysis.Frontiers in genetics · 2020Article
- Putative Pathobionts in HLA-B27-Associated Spondyloarthropathy.Frontiers in immunology · 2020Review
- Inflammatory bowel diseases and spondyloarthropathies: From pathogenesis to treatment.World journal of gastroenterology · 2019Review
- Biomarkers in Inflammatory Bowel Disease-Associated Spondyloarthritis: State of the Art and Unmet Needs.Journal of immunology research · 2019Review
- Autophagy-related IRGM genes confer susceptibility to ankylosing spondylitis in a Chinese female population: a case-control study.Genes and immunity · 2017Article
- NOD2/CARD15 gene mutations in patients with gouty arthritis.Bosnian journal of basic medical sciences · 2016Article
- Occult spondyloarthritis in inflammatory bowel disease.Clinical rheumatology · 2016Review
- The intestinal microbiome in spondyloarthritis.Current opinion in rheumatology · 2015Review
- Spondyloarthritis and the microbiome: new insights from an ancient hypothesis.Current rheumatology reports · 2015Review
- The role of the gut and microbes in the pathogenesis of spondyloarthritis.Best practice & research. Clinical rheumatology · 2014Review
- Spondyloarthritis: Gut inflammation in SpA: flagellin joins the dance?Nature reviews. Rheumatology · 2014Article
- Spondyloarthritis and inflammatory bowel disease. Comorbidity and treatment implications.Zeitschrift fur Rheumatologie · 2013Review
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe association between spondyloarthropathy and Crohn's disease is well known. A risk for evolution to Crohn's disease has already been shown in the subgroup of patients with spondyloarthropathy associated with chronic gut inflammation.
objectiveTo investigate whether the reported polymorphisms in the CARD15 gene, a susceptibility gene for Crohn's disease, are associated with the presence of preclinical intestinal inflammation observed in spondyloarthropathies.
methods104 patients with spondyloarthropathies were studied. All underwent ileocolonoscopy with biopsies between 1983 and 2004. The prevalence of three single nucleotide polymorphisms in the CARD15 gene (R702W, G908R, and 1007fs) was assessed using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR); the patients were compared with an ethnically matched Crohn's disease population and a control population.
resultsThe carrier frequency of R702W, G908R, or 1007fs variants in the spondyloarthropathy populations (20%) was similar to the control population (17%), but increased to 38% in the spondyloarthropathy subgroup with chronic gut inflammation. This frequency was significantly higher than in the other spondyloarthropathy subgroups (p = 0.001) or the control group (p = 0.006), but not different from the Crohn's disease group (49%) (NS). This indicates that CARD15 polymorphisms are associated with a higher risk for development of chronic gut inflammation.
conclusionsCARD15 gene polymorphisms clearly identify a subgroup of patients with spondyloarthropathies associated with chronic intestinal inflammation.
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