ArticleProceedings. Biological sciences2004
Adaptive evolution of HoxA-11 and HoxA-13 at the origin of the uterus in mammals.
Article in Proceedings. Biological sciences, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 36 citations in OpenAlex.
- Embryological Insights into the Origin of Epithelial Cancers of the Female Reproductive Tract.Cold Spring Harbor perspectives in medicine · 2023Review
- Regional effect on the molecular clock rate of protein evolution in Eutherian and Metatherian genomes.BMC ecology and evolution · 2021Article
- Developing a theoretical evolutionary framework to solve the mystery of parturition initiation.eLife · 2020Review
- Mammalian-specific ectodermal enhancers control the expression ofProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Transposable elements contribute to the genomic response to insecticides inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- A molecular footprint of limb loss: sequence variation of the autopodial identity gene Hoxa-13.Journal of molecular evolution · 2008Article
- Adaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammals.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Article
- Adaptive evolution of Hox-gene homeodomains after cluster duplications.BMC evolutionary biology · 2006Article
- The duplication of the Hox gene clusters in teleost fishes.Theory in biosciences = Theorie in den Biowissenschaften · 2004Article
- Molecular evolution of HoxA13 and the multiple origins of limbless morphologies in amphibians and reptiles.Genetics and molecular biologyArticle
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evolution of morphological characters is mediated by the evolution of developmental genes. Evolutionary changes can either affect cis-regulatory elements, leading to differences in their temporal and spatial regulation, or affect the coding region. Although there is ample evidence for the importance of cis-regulatory evolution, it has only recently been shown that transcription factors do not remain functionally equivalent during evolution. These results suggest that the evolution of transcription factors may play an active role in the evolution of development. To test this idea we investigated the molecular evolution of two genes essential for the development and function of the mammalian female reproductive organs, HoxA-11 and HoxA-13. We predicted that if coding-region evolution plays an active role in developmental evolution, then these genes should have experienced adaptive evolution at the origin of the mammalian female reproductive system. We report the sequences of HoxA-11 from basal mammalian and amniote taxa and analyse HoxA-11 and HoxA-13 for signatures of adaptive molecular evolution. The data demonstrate that these genes were under strong positive (directional) selection in the stem lineage of therian and eutherian mammals, coincident with the evolution of the uterus and vagina. These results support the idea that adaptive evolution of transcription factors can be an integral part in the evolution of novel structures.
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