Trial reportBMC psychiatry2004
S-adenosylmethionine (SAM-e) for the treatment of depression in people living with HIV/AIDS.
Trial report in BMC psychiatry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Pooled it
- S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders: A Clinician-Oriented Review of Research.The Journal of clinical psychiatry · 2017Pooled it
- S-adenosyl methionine (SAMe) for depression in adults.The Cochrane database of systematic reviews · 2016Pooled it
- (S)-S-adenosylmethionine in the treatment of pre-menstrual disorders in adult women: A protocol for an open-label pilot study.Contemporary clinical trials communications · 2024Article
- MAT2A-Mediated S-Adenosylmethionine Level in CD4Frontiers in immunology · 2021Article
- Biosynthesis of S-Adenosylmethionine by Magnetically Immobilized Escherichia coli Cells Highly Expressing a Methionine Adenosyltransferase Variant.Molecules (Basel, Switzerland) · 2017Article
- Progress in the microbial production of S-adenosyl-L-methionine.World journal of microbiology & biotechnology · 2016Review
- Anxiety and Methylenetetrahydrofolate Reductase Mutation Treated With S-Adenosyl Methionine and Methylated B Vitamins.Integrative medicine (Encinitas, Calif.) · 2016Article
- Preliminary results of a randomized controlled trial carried out with a fixed combination of S-adenosyl-L-methionine and betaine versus amitriptyline in patients with mild depression.International journal of general medicine · 2015Article
- Mood disorders and complementary and alternative medicine: a literature review.Neuropsychiatric disease and treatment · 2013Article
- Cobalamin deficiency, hyperhomocysteinemia, and dementia.Neuropsychiatric disease and treatment · 2010Article
- Complementary and alternative medicine therapies to promote healthy moods.Pediatric clinics of North America · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study reports on clinical data from an 8-week open-label study of 20 HIV-seropositive individuals, diagnosed with Major Depressive Disorder (DSM-IV), who were treated with SAM-e (S-Adenosylmethionine). SAM-e may be a treatment alternative for the management of depression in a population reluctant to add another "pill" or another set of related side effects to an already complex highly active antiretroviral therapy (HAART) regimen.
methodsThe Hamilton Rating Scale for Depression (HAM-D) and the Beck Depression Inventory (BDI) were used to assess depressive symptomatology from 1,2,4,6 and 8 weeks after initiation of treatment with SAM-e.
resultsData show a significant acute reduction in depressive symptomatology, as measured by both the HAM-D and the BDI instruments.
conclusionsSAM-e has a rapid effect evident as soon as week 1 (p < .001), with progressive decreases in depression symptom rating scores throughout the 8 week study.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.