ArticleBMC neuroscience2004
Bi-directional modulation of AMPA receptor unitary conductance by synaptic activity.
Article in BMC neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 70 citations in OpenAlex.
- Glutamate Receptors and Synaptic Plasticity in Health and Disease: A Personal Journey.Hippocampus · 2026Review
- Extended fear learning enhances excitatory and inhibitory synaptic transmission onto amygdala engram cells.Nature communications · 2025Article
- Activity-dependent diffusion trapping of AMPA receptors as a key step for expression of early LTP.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Tonic activin signaling shapes cellular and synaptic properties of CA1 neurons mainly in dorsal hippocampus.iScience · 2023Article
- PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus.Nature communications · 2021Article
- Differential sensitivity of three forms of hippocampal synaptic potentiation to depotentiation.Molecular brain · 2019Article
- AMPA-Type Glutamate Receptor Conductance Changes and Plasticity: Still a Lot of Noise.Neurochemical research · 2019Review
- Real Time Multiplicative Memory Amplification Mediated by Whole-Cell Scaling of Synaptic Response in Key Neurons.PLoS computational biology · 2017Article
- Modulation of Synaptic Plasticity by Exercise Training as a Basis for Ischemic Stroke Rehabilitation.Cellular and molecular neurobiology · 2017Review
- Lead Exposure Impairs Hippocampus Related Learning and Memory by Altering Synaptic Plasticity and Morphology During Juvenile Period.Molecular neurobiology · 2016Article
- Article
- Persistent CaMKII activation mediates learning-induced long-lasting enhancement of synaptic inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Conditional deletion of α-CaMKII impairs integration of adult-generated granule cells into dentate gyrus circuits and hippocampus-dependent learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Inhibitory interactions between phosphorylation sites in the C terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits.The Journal of biological chemistry · 2014Article
- Regulation of GluA1 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor function by protein kinase C at serine-818 and threonine-840.Molecular pharmacology · 2014Article
- Maximum likelihood estimation of biophysical parameters of synaptic receptors from macroscopic currents.Frontiers in cellular neuroscience · 2014Article
- GluA1 promotes the activity-dependent development of motor circuitry in the developing segmental spinal cord.Annals of the New York Academy of Sciences · 2013Review
- PKCα is required for inflammation-induced trafficking of extrasynaptic AMPA receptors in tonically firing lamina II dorsal horn neurons during the maintenance of persistent inflammatory pain.The journal of pain · 2013Article
- Article
- Posttranslational regulation of AMPA receptor trafficking and function.Current opinion in neurobiology · 2012Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundKnowledge of how synapses alter their efficiency of communication is central to the understanding of learning and memory. The most extensively studied forms of synaptic plasticity are long-term potentiation (LTP) and its counterpart long-term depression (LTD) of AMPA receptor-mediated synaptic transmission. In the CA1 region of the hippocampus, it has been shown that LTP often involves a rapid increase in the unitary conductance of AMPA receptor channels. However, LTP can also occur in the absence of any alteration in AMPA receptor unitary conductance. In the present study we have used whole-cell dendritic recording, failures analysis and non-stationary fluctuation analysis to investigate the mechanism of depotentiation of LTP.
resultsWe find that when LTP involves an increase in unitary conductance, subsequent depotentiation invariably involves the return of unitary conductance to pre-LTP values. In contrast, when LTP does not involve a change in unitary conductance then depotentiation also occurs in the absence of any change in unitary conductance, indicating a reduction in the number of activated receptors as the most likely mechanism.
conclusionsThese data show that unitary conductance can be bi-directionally modified by synaptic activity. Furthermore, there are at least two distinct mechanisms to restore synaptic strength from a potentiated state, which depend upon the mechanism of the previous potentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.