ArticlePLoS biology2004
Convergent evolution of chromosomal sex-determining regions in the animal and fungal kingdoms.
Article in PLoS biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers.
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Who cites it
133 citing papers in PubMed.
- Chromosome-scale genome assembly and characterization of Saccharomycopsis schoenii, a necrotrophic predatory yeast.G3 (Bethesda, Md.) · 2026Article
- Establishment of a congenic strain for the oyster mushroom reveals the structure and evolution of mating-type loci.PLoS genetics · 2026Article
- Mating-Type Loci Modulate Pathogenicity and Non-Sexual Development Through Autocrine Pheromone Signalling in the Asexual Fungus Fusarium oxysporum.Molecular plant pathology · 2026Article
- Domestication drives repeated evolution of sexual-asexual life cycle trade-offs in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The complex evolution and genomic dynamics of mating-type loci in Cryptococcus and Kwoniella.PLoS biology · 2025Article
- Tracing the evolution and genomic dynamics of mating-type loci inbioRxiv : the preprint server for biology · 2025Article
- The Fungal Kingdom as a Rosetta Stone for biological discovery.Current biology : CB · 2025Article
- Repeated loss of function at HD mating-type genes and of recombination in anther-smut fungi.Nature communications · 2025Article
- Genetic differentiation in the MAT-proximal region is not sufficient for suppressing recombination in Podospora anserina.G3 (Bethesda, Md.) · 2025Article
- Article
- Essential genes encoded by the mating-type locus of the human fungal pathogenbioRxiv : the preprint server for biology · 2024Article
- Distinct effect of calorie restriction between congenic mating types of Cryptococcus neoformans.Scientific reports · 2024Article
- Genome biology and evolution of mating-type loci in four cereal rust fungi.PLoS genetics · 2024Article
- Article
- Frequent transitions in mating-type locus chromosomal organization inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Frequent transitions in mating-type locus chromosomal organization inbioRxiv : the preprint server for biology · 2023Article
- On the evolution of variation in sexual reproduction through the prism of eukaryotic microbes.Proceedings of the National Academy of Sciences of the United States of America · 2023Review
- Stepwise recombination suppression around the mating-type locus in an ascomycete fungus with self-fertile spores.PLoS genetics · 2023Article
- Lessons learned: from mentored to mentor.The Journal of clinical investigation · 2023Article
- Onset and stepwise extensions of recombination suppression are common in mating-type chromosomes of Microbotryum anther-smut fungi.Journal of evolutionary biology · 2022Article
73 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
Abstract
Sexual identity is governed by sex chromosomes in plants and animals, and by mating type (MAT) loci in fungi. Comparative analysis of the MAT locus from a species cluster of the human fungal pathogen Cryptococcus revealed sequential evolutionary events that fashioned this large, highly unusual region. We hypothesize that MAT evolved via four main steps, beginning with acquisition of genes into two unlinked sex-determining regions, forming independent gene clusters that then fused via chromosomal translocation. A transitional tripolar intermediate state then converted to a bipolar system via gene conversion or recombination between the linked and unlinked sex-determining regions. MAT was subsequently subjected to intra- and interallelic gene conversion and inversions that suppress recombination. These events resemble those that shaped mammalian sex chromosomes, illustrating convergent evolution in sex-determining structures in the animal and fungal kingdoms.
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