ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Molecular determinants of ligand selectivity in a vertebrate odorant receptor.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 86 citations in OpenAlex.
- The genetic basis of the leafy seadragon's unique camouflage morphology and avenues for its efficient conservation derived from habitat modeling.Science China. Life sciences · 2023Article
- Detection and Modulation of Olfactory Sensing Receptors in Carnivorous Rainbow Trout (International journal of molecular sciences · 2022Article
- Coding of pheromones by vomeronasal receptors.Cell and tissue research · 2021Review
- Diving into the streams and waves of constitutive and regenerative olfactory neurogenesis: insights from zebrafish.Cell and tissue research · 2021Review
- Transcriptome Analysis of Zebrafish Olfactory Epithelium Reveal Sexual Differences in Odorant Detection.Genes · 2020Article
- Expansion of vomeronasal receptor genes (Communications biology · 2019Article
- Identification of olfactory receptor genes in the Japanese grenadier anchovyGenes & genomics · 2017Article
- The GPCR, class C, group 6, subtype A (GPRC6A) receptor: from cloning to physiological function.British journal of pharmacology · 2014Review
- Phospholipase C and diacylglycerol mediate olfactory responses to amino acids in the main olfactory epithelium of an amphibian.PloS one · 2014Article
- Role of a ubiquitously expressed receptor in the vertebrate olfactory system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Bimodal processing of olfactory information in an amphibian nose: odor responses segregate into a medial and a lateral stream.Cellular and molecular life sciences : CMLS · 2013Article
- Ancestral amphibian v2rs are expressed in the main olfactory epithelium.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Lineage-specific expansion of vomeronasal type 2 receptor-like (OlfC) genes in cichlids may contribute to diversification of amino acid detection systems.Genome biology and evolution · 2013Article
- Databases in SenseLab for the genomics, proteomics, and function of olfactory receptors.Methods in molecular biology (Clifton, N.J.) · 2013Article
- Relationship between amino acid properties and functional parameters in olfactory receptors and discrimination of mutants with enhanced specificity.BMC bioinformatics · 2012Article
- Specificities of olfactory receptor neuron responses to amino acids in the black bullhead catfish (Ameiurus melas).Pflugers Archiv : European journal of physiology · 2010Article
- Purification, Characterization, and Effect of Thiol Compounds on Activity of the Erwinia carotovora L-Asparaginase.Enzyme research · 2010Article
- Olfactory neural circuitry for attraction to amino acids revealed by transposon-mediated gene trap approach in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- A new challenge-development of test systems for the infochemical effect.Environmental science and pollution research international · 2009Review
- Genomic organization and evolution of the vomeronasal type 2 receptor-like (OlfC) gene clusters in Atlantic salmon, Salmo salar.Molecular biology and evolution · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The identification of the chemical structure of an odorant by the vertebrate olfactory system is thought to occur through the combinatorial activity from multiple receptors, each tuned to recognize different chemical features. What are the molecular determinants underlying the selectivity of individual odorant receptors for their cognate ligands? To address this question, we performed molecular modeling and site-directed mutagenesis on the ligand-binding region of two orthologous amino acid odorant receptors belonging to the "C family" of G-protein-coupled receptors in goldfish and zebrafish. We identified the critical ligand-receptor interactions that afford ligand binding as well as selectivity for different amino acids. Moreover, predictions regarding binding pocket structure allowed us to alter, in a predictable manner, the receptor preferences for different ligands. These results reveal how this class of odorant receptor has evolved to accommodate ligands of varying chemical structure and further illuminate the molecular principles underlying ligand recognition and selectivity in this family of chemosensory receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.