ArticleLearning & memory (Cold Spring Harbor, N.Y.)
Olfactory fear conditioning induces field potential potentiation in rat olfactory cortex and amygdala.
Article in Learning & memory (Cold Spring Harbor, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Encoding of odor information and reward anticipation in anterior cortical amygdaloid nucleus.iScience · 2026Article
- Experience-dependent critical period for synaptic plasticity in the rat olfactory amygdala.Frontiers in synaptic neuroscience · 2026Review
- A role for circuitry of the cortical amygdala in excessive alcohol drinking, withdrawal, and alcohol use disorder.Alcohol (Fayetteville, N.Y.) · 2024Review
- Retrieval of olfactory fear memory alters cell proliferation and expression of pCREB and pMAPK in the corticomedial amygdala and piriform cortex.Chemical senses · 2022Article
- Sex-Specific Neural Networks of Cued Threat Conditioning: A Pilot Study.Frontiers in systems neuroscience · 2022Article
- Background stimulus delays detection of target stimulus in a familiar odor-odor combination.Scientific reports · 2021Article
- Neural processing of the reward value of pleasant odorants.Current biology : CB · 2021Article
- Aversive Learning Increases Release Probability of Olfactory Sensory Neurons.Current biology : CB · 2020Article
- An Evolutionarily Threat-Relevant Odor Strengthens Human Fear Memory.Frontiers in neuroscience · 2020Article
- Chronic Exposure to High Altitude: Synaptic, Astroglial and Memory Changes.Scientific reports · 2019Article
- Aversive learning-induced plasticity throughout the adult mammalian olfactory system: insights across development.Journal of bioenergetics and biomembranes · 2019Review
- Pavlovian Olfactory Fear Conditioning: Its Neural Circuity and Importance for Understanding Clinical Fear-Based Disorders.Frontiers in molecular neuroscience · 2019Review
- The Divergent Effects of CDPPB and Cannabidiol on Fear Extinction and Anxiety in a Predator Scent Stress Model of PTSD in Rats.Frontiers in behavioral neuroscience · 2019Article
- Pheromone-Induced Odor Associative Fear Learning in Rats.Scientific reports · 2018Article
- Paradoxical olfactory function in combat veterans: The role of PTSD and odor factors.Military psychology : the official journal of the Division of Military Psychology, American Psychological Association · 2018Article
- Ecologically relevant neurobehavioral assessment of the development of threat learning.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Review
- De Novo Emergence of Odor Category Representations in the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- The olfactory thalamus: unanswered questions about the role of the mediodorsal thalamic nucleus in olfaction.Frontiers in neural circuits · 2015Review
- The smell of fear: innate threat of 2,5-dihydro-2,4,5-trimethylthiazoline, a single molecule component of a predator odor.Frontiers in neuroscience · 2015Review
- Differential involvement of amygdala and cortical NMDA receptors activation upon encoding in odor fear memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The widely used Pavlovian fear-conditioning paradigms used for studying the neurobiology of learning and memory have mainly used auditory cues as conditioned stimuli (CS). The present work assessed the neural network involved in olfactory fear conditioning, using olfactory bulb stimulation-induced field potential signal (EFP) as a marker of plasticity in the olfactory pathway. Training consisted of a single training session including six pairings of an odor CS with a mild foot-shock unconditioned stimulus (US). Twenty-four hours later, the animals were tested for retention of the CS as assessed by the amount of freezing exhibited in the presence of the learned odor. Behavioral data showed that trained animals exhibited a significantly higher level of freezing in response to the CS than control animals. In the same animals, EFPs were recorded in parallel in the anterior piriform cortex (aPC), posterior piriform cortex (pPC), cortical nucleus of the amygdala (CoA), and basolateral nucleus of the amygdala (BLA) following electrical stimulation of the olfactory bulb. Specifically, EFPs recorded before (baseline) and after (during the retention test) training revealed that trained animals exhibited a lasting increase (present before and during presentation of the CS) in EFP amplitude in CoA, which is the first amygdaloid target of olfactory information. In addition, a transient increase was observed in pPC and BLA during presentation of the CS. These data indicate that the olfactory and auditory fear-conditioning neural networks have both similarities and differences, and suggest that the fear-related behaviors in each sensory system may have at least some distinct characteristics.
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