ReviewIntensive care medicine2004
Antibiotic pharmacokinetic and pharmacodynamic considerations in critical illness.
Review in Intensive care medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07681544 (Meropenem Dosing in Critically Ill Patients), which is not on this map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Meropenem Dosing in Critically Ill Patients: Early Evaluation of Plasma Concentrations and Minimum Inhibitory Concentration
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.
- Antibiotics in critically ill patients: a systematic review of the pharmacokinetics of β-lactams.Critical care (London, England) · 2011Pooled it
- Applying pharmacokinetic/pharmacodynamic measurements for linezolid in critically ill patients: optimizing efficacy and reducing resistance occurrence.European journal of clinical pharmacology · 2022Trial
- Population Pharmacokinetic Model to Optimize Cefotaxime Dosing Regimen in Critically Ill Children.Clinical pharmacokinetics · 2018Trial
- Population pharmacokinetics of imipenem in critically ill patients with suspected ventilator-associated pneumonia and evaluation of dosage regimens.British journal of clinical pharmacology · 2014Trial
- Pharmacokinetics of colistin in critically ill patients with multidrug-resistant Gram-negative bacilli infection.European journal of clinical pharmacology · 2013Trial
- Amikacin population pharmacokinetics in critically ill Kuwaiti patients.BioMed research international · 2013Trial
- Pharmacokinetics of linezolid in septic patients with and without extended dialysis.European journal of clinical pharmacology · 2010Trial
- Population pharmacokinetics and pharmacodynamics of meropenem in critically ill patients with renal impairment or on continuous renal replacement therapy.European journal of clinical pharmacology · 2025Article
- DOSAGE: Dataset for Optimized Safe Antibiotic Guidelines and Estimates.Scientific data · 2025Article
- Antibiotic-Drug Interactions in the Intensive Care Unit: A Literature Review.Antibiotics (Basel, Switzerland) · 2024Review
- "CATCH" Study: Correct Antibiotic Therapy in Continuous Hemofiltration in the Critically Ill in Continuous Renal Replacement Therapy: A Prospective Observational Study.Antibiotics (Basel, Switzerland) · 2022Article
- Antibiotic Therapy in the Critically Ill with Acute Renal Failure and Renal Replacement Therapy: A Narrative Review.Antibiotics (Basel, Switzerland) · 2022Review
- Distribution of therapeutic monoclonal antibodies into ascites in advanced gastric cancer patients with peritoneal metastasis: case reports and literature review.Cancer chemotherapy and pharmacology · 2022Review
- TDM-guided medication of polymyxin B in a patient with CRKP-induced bloodstream infection: a case report.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- Megalin-targeting liposomes for placental drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2020Article
- Antibiotics can be used to contain drug-resistant bacteria by maintaining sufficiently large sensitive populations.PLoS biology · 2020Article
- The effect of therapeutic drug monitoring of beta-lactam and fluoroquinolones on clinical outcome in critically ill patients: the DOLPHIN trial protocol of a multi-centre randomised controlled trial.BMC infectious diseases · 2020Article
- Moxifloxacin in Chronic Obstructive Pulmonary Disease: Pharmacokinetics and Penetration into Bronchial Secretions in Ward and Intensive Care Unit Patients.Antimicrobial agents and chemotherapy · 2019Article
- Pharmacokinetics of cefuroxime in infants and neonates undergoing cardiac surgery.British journal of clinical pharmacology · 2018Article
- Closed-Loop- and Decision-Assist-Guided Fluid Therapy of Human Hemorrhage.Critical care medicine · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany factors over which there may be little control may influence the response of a patient to therapy. However, therapy with antibiotics can be readily optimised. DISCUSSION: Concentration-dependent agents such as aminoglycosides appear effective and to entail fewer side effects when given in large, infrequent doses. There is also evidence that time-dependent antibiotics often fail to reach adequate concentrations throughout the treatment period. To date no randomised controlled prospective trial has demonstrated improvement in clinical outcome following infusion rather than intermittent boluses of time-dependent antibiotics. Critical illness alters antibiotic pharmacokinetics principally through increases in volume of distribution. Other than glycopeptides and aminoglycosides, antibiotic blood concentrations are rarely monitored and therefore adequate concentrations can only be inferred from clinical response.
conclusionsFailure to respond within the first few days of empirical treatment may be due to antibiotic resistance or inadequate doses. Therefore the same rigor should be applied to achieving adequate antibiotic concentrations as is applied to inotropes, which are titrated to achieve predetermined physiological targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.