ArticleJournal of molecular medicine (Berlin, Germany)2005
Association of polymorphisms of the androgen receptor and klotho genes with bone mineral density in Japanese women.
Article in Journal of molecular medicine (Berlin, Germany), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 93 citations in OpenAlex.
- Klotho reduces the risk of osteoporosis in postmenopausal women: a cross-sectional study of the National Health and Nutrition Examination Survey (NHANES).BMC endocrine disorders · 2023Article
- Expression of Renal Vitamin D and Phosphatonin-Related Genes in a Sheep Model of Osteoporosis.Animals : an open access journal from MDPI · 2021Article
- The influence of microsatellite polymorphisms in sex steroid receptor genes ESR1, ESR2 and AR on sex differences in brain structure.NeuroImage · 2020Article
- KLOTHO polymorphisms and age-related outcomes in community-dwelling older subjects: The São Paulo Ageing & Health (SPAH) Study.Scientific reports · 2020Article
- Antiaging Factor Klotho Retards the Progress of Intervertebral Disc Degeneration through the Toll-Like Receptor 4-NF-International journal of cell biology · 2020Article
- Klotho: An Elephant in Aging Research.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Review
- Association of Serum Klotho with Loss of Bone Mineral Density and Fracture Risk in Older Adults.Journal of the American Geriatrics Society · 2016Article
- Genetic Variants in KLOTHO Associate With Cognitive Function in the Oldest Old Group.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Article
- G-395A polymorphism in the promoter region of the KLOTHO gene associates with reduced cognitive impairment among the oldest old.Age (Dordrecht, Netherlands) · 2016Article
- Serum 25-Hydroxyvitamin D, Plasma Klotho, and Lower-Extremity Physical Performance Among Older Adults: Findings From the InCHIANTI Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients.International journal of endocrinology · 2015Article
- The association between KL polymorphism and prostate cancer risk in Korean patients.Molecular biology reports · 2014Article
- Androgen receptor polyglutamine repeat number: models of selection and disease susceptibility.Evolutionary applications · 2013Article
- The role of Klotho in energy metabolism.Nature reviews. Endocrinology · 2012Review
- Klotho locus, metabolic traits, and serum hemoglobin in hospitalized older patients: a genetic association analysis.Age (Dordrecht, Netherlands) · 2012Article
- The effects of oxygen tension and antiaging factor Klotho on Wnt signaling in nucleus pulposus cells.Arthritis research & therapy · 2012Article
- Plasma klotho and mortality risk in older community-dwelling adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2011Article
- Genetic analysis of vertebral trabecular bone density and cross-sectional area in older men.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2011Article
- Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk.PLoS genetics · 2011Article
- Association of polymorphisms in the klotho gene with severity of non-diabetic ESRD in African Americans.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic variants of the androgen receptor and klotho protein may contribute to variation in bone mass as well as to predisposition to osteoporosis. The relationship of a CAG repeat polymorphism of the androgen receptor gene (AR) and of a -395G-->A polymorphism of the klotho gene (KL) to bone mineral density (BMD) in Japanese women was examined in a population-based study. The subjects (1,101 and 1,110 women for AR and KL polymorphisms, respectively) were aged 40-79 years and were randomly recruited to a population-based prospective cohort study of aging and age-related diseases. BMD for the total body, lumbar spine, right femoral neck, right trochanter, and right Ward's triangle was measured by dual-energy X-ray absorptiometry. Genotypes for the AR and KL polymorphisms were determined by polymerase chain reaction based assays. The number of CAG repeats of AR was inversely correlated with BMD for the lumbar spine in premenopausal women but not in postmenopausal women. The (CAG)(n</=22) and (CAG)(n>/=23) alleles were designated S and L, respectively. Among premenopausal women, BMD for the total body was significantly lower in subjects with the LL genotype than in those with the SS genotype or those in the combined group of SS and SL genotypes. In contrast, BMD was not associated with AR genotype in postmenopausal women. Among all women, BMD for the lumbar spine was significantly lower in subjects with the GG genotype of the -395G-->A polymorphism of KL than in those with the AA genotype. BMD was not associated with -395G-->A genotype among premenopausal women. In postmenopausal women, BMD for the total body or lumbar spine tended to be lower in subjects with the GG genotype than in those with the AA genotype or those in the combined group of GA and AA genotypes. These results suggest that AR is a susceptibility gene for reduced BMD in premenopausal Japanese women, and that KL is a susceptibility gene for reduced BMD in all women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.