ArticleGenome biology2004
Phylogenomic evidence supports past endosymbiosis, intracellular and horizontal gene transfer in Cryptosporidium parvum.
Article in Genome biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed, 156 citations in OpenAlex.
- The history of cryptosporidiosis.Parasites & vectors · 2026Review
- Diurnal Rhythms in the Red Seaweed Gracilariopsis chorda are Characterized by Unique Regulatory Networks of Carbon Metabolism.Molecular biology and evolution · 2024Article
- Metagenomic analysis reveals the relationship between intestinal protozoan parasites and the intestinal microecological balance in calves.Parasites & vectors · 2023Article
- The Long and Short of Next Generation Sequencing forFrontiers in cellular and infection microbiology · 2022Review
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- A mutagenesis screen for essential plastid biogenesis genes in human malaria parasites.PLoS biology · 2019Article
- MTGIpick allows robust identification of genomic islands from a single genome.Briefings in bioinformatics · 2018Article
- Functional horizontal gene transfer from bacteria to eukaryotes.Nature reviews. Microbiology · 2018Review
- The apicoplast: now you see it, now you don't.International journal for parasitology · 2017Review
- Re-analyses of "Algal" Genes Suggest a Complex Evolutionary History of Oomycetes.Frontiers in plant science · 2017Article
- Horizontal transfer of β-carbonic anhydrase genes from prokaryotes to protozoans, insects, and nematodes.Parasites & vectors · 2016Article
- Beg, Borrow and Steal: Three Aspects of Horizontal Gene Transfer in the Protozoan Parasite, Cryptosporidium parvum.PLoS pathogens · 2016Article
- Factors mediating plastid dependency and the origins of parasitism in apicomplexans and their close relatives.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Prokaryotic ancestry and gene fusion of a dual localized peroxiredoxin in malaria parasites.Microbial cell (Graz, Austria) · 2015Article
- A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium.The Lancet. Infectious diseases · 2015Review
- The Cryptosporidium parvum ApiAP2 gene family: insights into the evolution of apicomplexan AP2 regulatory systems.Nucleic acids research · 2014Article
- What was the real contribution of endosymbionts to the eukaryotic nucleus? Insights from photosynthetic eukaryotes.Cold Spring Harbor perspectives in biology · 2014Review
- A recently transferred cluster of bacterial genes in Trichomonas vaginalis--lateral gene transfer and the fate of acquired genes.BMC evolutionary biology · 2014Article
- A plastid without a genome: evidence from the nonphotosynthetic green algal genus Polytomella.Plant physiology · 2014Article
6 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe apicomplexan parasite Cryptosporidium parvum is an emerging pathogen capable of causing illness in humans and other animals and death in immunocompromised individuals. No effective treatment is available and the genome sequence has recently been completed. This parasite differs from other apicomplexans in its lack of a plastid organelle, the apicoplast. Gene transfer, either intracellular from an endosymbiont/donor organelle or horizontal from another organism, can provide evidence of a previous endosymbiotic relationship and/or alter the genetic repertoire of the host organism. Given the importance of gene transfers in eukaryotic evolution and the potential implications for chemotherapy, it is important to identify the complement of transferred genes in Cryptosporidium.
resultsWe have identified 31 genes of likely plastid/endosymbiont (n = 7) or prokaryotic (n = 24) origin using a phylogenomic approach. The findings support the hypothesis that Cryptosporidium evolved from a plastid-containing lineage and subsequently lost its apicoplast during evolution. Expression analyses of candidate genes of algal and eubacterial origin show that these genes are expressed and developmentally regulated during the life cycle of C. parvum.
conclusionsCryptosporidium is the recipient of a large number of transferred genes, many of which are not shared by other apicomplexan parasites. Genes transferred from distant phylogenetic sources, such as eubacteria, may be potential targets for therapeutic drugs owing to their phylogenetic distance or the lack of homologs in the host. The successful integration and expression of the transferred genes in this genome has changed the genetic and metabolic repertoire of the parasite.
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