ArticlePLoS biology2004
Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse.
Article in PLoS biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
119 citing papers in PubMed, 226 citations in OpenAlex.
- Behavioral characterization of a novel Cisd2 mutant mouse.Behavioural brain research · 2021Article
- Genetic determinants of ammonia-induced acute lung injury in mice.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Mouse genome-wide association and systems genetics identifies Lhfp as a regulator of bone mass.PLoS genetics · 2019Article
- In silico mapping of quantitative trait loci (QTL) regulating the milk ionome in mice identifies a milk iron locus on chromosome 1.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- Haplotypes on pig chromosome 3 distinguish metabolically healthy from unhealthy obese individuals.PloS one · 2017Article
- Genome-Wide Association Mapping for Female Infertility in Inbred Mice.G3 (Bethesda, Md.) · 2016Article
- Article
- Exploiting expression patterns across multiple tissues to map expression quantitative trait loci.BMC bioinformatics · 2016Article
- In-silico QTL mapping of postpubertal mammary ductal development in the mouse uncovers potential human breast cancer risk loci.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Article
- Immune cell-based screening assay for response to anticancer agents: applications in pharmacogenomics.Pharmacogenomics and personalized medicine · 2015Article
- Genome-wide association mapping of acute lung injury in neonatal inbred mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- FVB/NJ mice demonstrate a youthful sensitivity to noise-induced hearing loss and provide a useful genetic model for the study of neural hearing loss.Audiology and neurotology. Extra · 2014Article
- Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration.PloS one · 2014Article
- A large QTL for fear and anxiety mapped using an F2 cross can be dissected into multiple smaller QTLs.Genes, brain, and behavior · 2013Article
- Functional genomic assessment of phosgene-induced acute lung injury in mice.American journal of respiratory cell and molecular biology · 2013Article
- High-precision genetic mapping of behavioral traits in the diversity outbred mouse population.Genes, brain, and behavior · 2013Article
- An integrative genomic analysis of the superior fecundity phenotype in QSi5 mice.Molecular biotechnology · 2013Article
- QTL analysis of dietary obesity in C57BL/6byj X 129P3/J F2 mice: diet- and sex-dependent effects.PloS one · 2013Article
- Natural genetic variation of integrin alpha L (Itgal) modulates ischemic brain injury in stroke.PLoS genetics · 2013Article
- Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene.PloS one · 2013Article
59 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
Rapid expansion of available data, both phenotypic and genotypic, for multiple strains of mice has enabled the development of new methods to interrogate the mouse genome for functional genetic perturbations. In silico mapping provides an expedient way to associate the natural diversity of phenotypic traits with ancestrally inherited polymorphisms for the purpose of dissecting genetic traits. In mouse, the current single nucleotide polymorphism (SNP) data have lacked the density across the genome and coverage of enough strains to properly achieve this goal. To remedy this, 470,407 allele calls were produced for 10,990 evenly spaced SNP loci across 48 inbred mouse strains. Use of the SNP set with statistical models that considered unique patterns within blocks of three SNPs as an inferred haplotype could successfully map known single gene traits and a cloned quantitative trait gene. Application of this method to high-density lipoprotein and gallstone phenotypes reproduced previously characterized quantitative trait loci (QTL). The inferred haplotype data also facilitates the refinement of QTL regions such that candidate genes can be more easily identified and characterized as shown for adenylate cyclase 7.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.