ArticleBiophysical journal2005
Mechanics of transient platelet adhesion to von Willebrand factor under flow.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 74 citations in OpenAlex.
- Platelet Biorheology and Mechanobiology in Thrombosis and Hemostasis: Perspectives from Multiscale Computation.International journal of molecular sciences · 2024Review
- A Multiscale Model for Shear-Mediated Platelet Adhesion Dynamics: Correlating In Silico with In Vitro Results.Annals of biomedical engineering · 2023Article
- A microfluidic method to investigate platelet mechanotransduction under extensional strain.Research and practice in thrombosis and haemostasis · 2023Article
- An extensional strain sensing mechanosome drives adhesion-independent platelet activation at supraphysiological hemodynamic gradients.BMC biology · 2022Article
- In Vitro Measurements of Shear-Mediated Platelet Adhesion Kinematics as Analyzed through Machine Learning.Annals of biomedical engineering · 2021Article
- Effect of upstream priming on transient downstream platelet-substrate interactions.Colloids and surfaces. B, Biointerfaces · 2021Article
- Rapid analysis of streaming platelet images by semi-unsupervised learning.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · 2021Article
- Thrombosis in Cerebral Aneurysms and the Computational Modeling Thereof: A Review.Frontiers in physiology · 2018Review
- Binary agonist surface patterns prime platelets for downstream adhesion in flowing whole blood.Biointerphases · 2017Article
- The Effect of Hematocrit on Platelet Adhesion: Experiments and Simulations.Biophysical journal · 2016Article
- Systems Analysis of Thrombus Formation.Circulation research · 2016Review
- A Multiple Time Stepping Algorithm for Efficient Multiscale Modeling of Platelets Flowing in Blood Plasma.Journal of computational physics · 2015Article
- A phenomenological particle-based platelet model for simulating filopodia formation during early activation.International journal for numerical methods in biomedical engineering · 2015Article
- Multiscale Particle-Based Modeling of Flowing Platelets in Blood Plasma Using Dissipative Particle Dynamics and Coarse Grained Molecular Dynamics.Cellular and molecular bioengineering · 2014Article
- Platelet GpIba binding to von Willebrand Factor under fluid shear:contributions of the D′D3-domain, A1-domain flanking peptide and O-linked glycans.Journal of the American Heart Association · 2014Article
- Three-dimensional multi-scale model of deformable platelets adhesion to vessel wall in blood flow.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2014Article
- Adhesive dynamics.Journal of biomechanical engineering · 2014Review
- Physical biology in cancer. 2. The physical biology of circulating tumor cells.American journal of physiology. Cell physiology · 2014Review
- Platelet size and density affect shear-induced thrombus formation in tortuous arterioles.Physical biology · 2013Article
- Simulation of platelet, thrombus and erythrocyte hydrodynamic interactions in a 3D arteriole with in vivo comparison.PloS one · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
A primary and critical step in platelet attachment to injured vascular endothelium is the formation of reversible tether bonds between the platelet glycoprotein receptor Ibalpha and the A1 domain of surface-bound von Willebrand factor (vWF). Due to the platelet's unique ellipsoidal shape, the force mechanics involved in its tether bond formation differs significantly from that of leukocytes and other spherical cells. We have investigated the mechanics of platelet tethering to surface-immobilized vWF-A1 under hydrodynamic shear flow. A computer algorithm was used to analyze digitized images recorded during flow-chamber experiments and track the microscale motions of platelets before, during, and after contact with the surface. An analytical two-dimensional model was developed to calculate the motion of a tethered platelet on a reactive surface in linear shear flow. Through comparison of the theoretical solution with experimental observations, we show that attachment of platelets occurs only in orientations that are predicted to result in compression along the length of the platelet and therefore on the bond being formed. These results suggest that hydrodynamic compressive forces may play an important role in initiating tether bond formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.