ArticleBiophysical journal2005
Nanoscale features of fibronectin fibrillogenesis depend on protein-substrate interaction and cytoskeleton structure.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 38 citations in OpenAlex.
- Large-scale topographical screen for investigation of physical neural-guidance cues.Scientific reports · 2015Article
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- Cell-material interactions on biphasic polyurethane matrix.Journal of biomedical materials research. Part A · 2013Article
- The role of surface chemistry-induced cell characteristics on nonviral gene delivery to mouse fibroblasts.Journal of biological engineering · 2012Article
- Biophysics of substrate interaction: influence on neural motility, differentiation, and repair.Developmental neurobiology · 2011Review
- The relative importance of topography and RGD ligand density for endothelial cell adhesion.PloS one · 2011Article
- Immobilization of growth factors on solid supports for the modulation of stem cell fate.Nature protocols · 2010Article
- How do cells make decisions: engineering micro- and nanoenvironments for cell migration.Journal of oncology · 2010Article
- Dissecting the impact of matrix anchorage and elasticity in cell adhesion.Biophysical journal · 2009Article
- The KIDSTEM European Research Training Network: Developing a Stem Cell Based Therapy to Replace Nephrons Lost through Reflux Nephropathy.Organogenesis · 2007Article
- Fibronectin fibril pattern displays the force balance of cell-matrix adhesion.European biophysics journal : EBJ · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell-reorganized fibronectin layers on polymer films providing a gradation of the binding strength between protein and substrate were analyzed by combined fluorescence and scanning force microscopy. The nanoscale fibronectin patterns exhibited paired parallel fibrils with characteristic spacings of 156, 233, 304, and 373 nm. These spacings depend on the interaction of fibronectin with the substrate: at enhanced fibronectin-substrate anchorage the cells form larger stress fibers, which are assembled by alpha-actinin cross-linked pairs of actin filaments subunits at the focal adhesions. A ubiquitous repeating unit of approximately 71 nm was found within these characteristic distances. We conclude that the dimensions of the actin stress fibers reflect the binding strength of fibronectin to the polymer substrate and act--in turn--as a template for the reorganization of fibronectin into surface-bound nanofibrils with characteristic spacings. This explanation was confirmed by data showing the alpha-actinin/fibronectin colocalization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.