ArticlePflugers Archiv : European journal of physiology1992
Properties of the potassium conductances of principal cells of rat cortical collecting ducts.
Article in Pflugers Archiv : European journal of physiology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Role and mechanisms of regulation of the basolateral KActa physiologica (Oxford, England) · 2017Review
- Regulation of potassium (K) handling in the renal collecting duct.Pflugers Archiv : European journal of physiology · 2009Review
- Molecular diversity and regulation of renal potassium channels.Physiological reviews · 2005Review
- Inhibition of protein-tyrosine phosphatase stimulates the dynamin-dependent endocytosis of ROMK1.The Journal of biological chemistry · 2002Article
- Basolateral membrane targeting of a renal-epithelial inwardly rectifying potassium channel from the cortical collecting duct, CCD-IRK3, in MDCK cells.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- K+ channels in the basolateral membrane of rat cortical collecting duct.Pflugers Archiv : European journal of physiology · 1993Article
- Cation specificity and pharmacological properties of the Ca(2+)-dependent K+ channel of rat cortical collecting ducts.Pflugers Archiv : European journal of physiology · 1993Article
- Ion conductances of isolated cortical collecting duct cells.Pflugers Archiv : European journal of physiology · 1992Article
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
In this study we examined by impalement techniques properties of the macroscopic K+ conductances in the luminal and basolateral membrane of principal cells from isolated perfused cortical collecting ducts (CCD) of the rat. Both membranes possess a dominating K+ conductance. Compared to their behaviour with K+, both membranes appear much less permeable to NH+4 and Rb+, and the K+ conductances of both membranes are inhibited by these cations. In light of these findings, it is very unlikely that significant amounts of NH+4, which is secreted in the CCD, cross the principal cells as NH+4. Several inhibitors with known effects on K+ channels in patch-clamp studies have been examined. Tetraethylammonium, which inhibits the excised K+ channels of these cells, has no effect on the macroscopic K+ conductances of either membrane. Verapamil, which inhibits the K+ channels in the luminal membrane, acts predominantly on the basolateral membrane K+ conductance in the intact tubule. Therefore, some of the macroscopic properties of the K+ conductances are distinct from those of single channels thus far observed in patch-clamp studies.
Indexed as
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Registered trials
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