ArticleOncogene2005
Transcript profiling of Wilms tumors reveals connections to kidney morphogenesis and expression patterns associated with anaplasia.
Article in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Article
- Bromodomain 4 inhibition leads to MYCN downregulation in Wilms tumor.Pediatric blood & cancer · 2022Article
- The non-human primate kidney transcriptome in fetal development.Journal of medical primatology · 2018Article
- Tissue expression of retinoic acid receptor alpha and CRABP2 in metastatic nephroblastomas.Diagnostic pathology · 2018Article
- HMGA2 overexpression predicts relapse susceptibility of blastemal Wilms tumor patients.Oncotarget · 2017Article
- CRABP-II enhances pancreatic cancer cell migration and invasion by stabilizing interleukin 8 expression.Oncotarget · 2017Article
- Overexpression of Transforming Acidic Coiled Coil‑Containing Protein 3 Reflects Malignant Characteristics and Poor Prognosis of Glioma.International journal of molecular sciences · 2017Article
- Wilms' tumor susceptibility: possible involvement of FOXP3 and CXCL12 genes.Molecular and cellular pediatrics · 2016Article
- Anaplastic histology Wilms' tumors registered to the Japan Wilms' Tumor Study Group are less aggressive than that in the National Wilms' Tumor Study 5.Pediatric surgery international · 2016Article
- Recurrent somatic mutation in DROSHA induces microRNA profile changes in Wilms tumour.Nature communications · 2014Article
- Development of the renal arterioles.Journal of the American Society of Nephrology : JASN · 2011Review
- FGF/EGF signaling regulates the renewal of early nephron progenitors during embryonic development.Development (Cambridge, England) · 2011Article
- Retinoic acid pathway activity in Wilms tumors and characterization of biological responses in vitro.Molecular cancer · 2011Article
- Temporal blastemal cell gene expression analysis in the kidney reveals new Wnt and related signaling pathway genes to be essential for Wilms' tumor onset.Cell death & disease · 2011Article
- Deletions of 16q in Wilms tumors localize to blastemal-anaplastic cells and are associated with reduced expression of the IRXB renal tubulogenesis gene cluster.The American journal of pathology · 2010Article
- Candidate genes and potential targets for therapeutics in Wilms' tumour.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2010Review
- Reduced expression of autotaxin predicts survival in uveal melanoma.The British journal of ophthalmology · 2007Article
- CITED1 expression in Wilms' tumor and embryonic kidney.Neoplasia (New York, N.Y.) · 2007Article
- Vascular endothelial growth factor (VEGF) is suppressed in WT1-transfected LNCaP cells.Gene expression · 2006Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Anaplasia (unfavorable histology) is associated with therapy resistance and poor prognosis of Wilms tumor, but the molecular basis for this phenotype is unclear. Here, we used a cDNA array with 9240 clones relevant to cancer biology and/or kidney development to examine the expression profiles of 54 Wilms tumors, five normal kidneys and fetal kidney. By linking genes differentially expressed between fetal kidney and Wilms tumors to kidney morphogenesis, we found that genes expressed at a higher level in Wilms tumors tend to be expressed more in uninduced metanephrogenic mesenchyme or blastema than in their differentiated structures. Conversely, genes expressed at a lower level in Wilms tumors tend to be expressed less in uninduced metanephrogenic mesenchyme or blastema. We also identified 97 clones representing 76 Unigenes or unclustered ESTs that clearly separate anaplastic Wilms tumors from tumors with favorable histology. Genes in this set provide insight into the nature of the abnormal nuclear morphology of anaplastic tumors and may facilitate identification of molecular targets to improve their responsiveness to treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.