ReviewImmunologic research2004
Osteoblast responses to bacterial pathogens: a previously unappreciated role for bone-forming cells in host defense and disease progression.
Review in Immunologic research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 97 citations in OpenAlex.
- [Chronic MRSA periprosthetic joint infection induces formation of mature tertiary lymphoid structures and osteolysis in mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- Osteomyelitis.Nature reviews. Disease primers · 2026Review
- Article
- Osteoimmunology: interactions of the bone and immune system.Frontiers in immunology · 2026Review
- Synergistic integration of biomaterials in orthopedic implantation for infection preventing and tissue engineering.Regenerative biomaterials · 2026Review
- Article
- Programmed Transformation of Osteogenesis Microenvironment by a Multifunctional Hydrogel to Enhance Repair of Infectious Bone Defects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A natural killer cell mimic against intracellular pathogen infections.Science advances · 2024Article
- The 2023 Orthopaedic Research Society's International Consensus Meeting on musculoskeletal infection: Summary from the host immunity section.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Non-biofilm-forming Staphylococcus epidermidis planktonic cell supernatant induces alterations in osteoblast biological function.Scientific reports · 2024Article
- Article
- Staphylococcus aureus Infection Induces the Production of the Neutrophil Chemoattractants CXCL1, CXCL2, CXCL3, CXCL5, CCL3, and CCL7 by Murine Osteoblasts.Infection and immunity · 2023Article
- Photoactivated antibiotics to treat intracellular infection of bacteria.Nanoscale advances · 2023Article
- Substance P Exacerbates the Inflammatory and Pro-osteoclastogenic Responses of Murine Osteoclasts and Osteoblasts to Staphylococcus aureus.Inflammation · 2023Article
- Dual-functional composite scaffolds for inhibiting infection and promoting bone regeneration.Materials today. Bio · 2022Review
- Human Osteoblast-Conditioned Media Can InfluenceInternational journal of molecular sciences · 2022Article
- Osteocytes directly regulate osteolysis via MYD88 signaling in bacterial bone infection.Nature communications · 2022Article
- Induction of protective interferon-β responses in murine osteoblasts followingFrontiers in microbiology · 2022Article
- Lunate bone loss associated withTrauma case reports · 2021Article
- Vitamin K alleviates bone calcium loss caused by Salmonella Enteritidis through carboxylation of osteocalcin.Journal of animal science and biotechnology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Although the primary roles of osteoblasts are to synthesize the components of bone matrix and to regulate the activity of bone resorbing osteoclasts, there is growing realization that osteoblasts have an additional function during bone diseases, such as osteomyelitis. Based on our recent studies, we propose a novel role for osteoblasts during bacterial infections of bone, namely, the initiation and maintenance of inflammatory immune responses. In this article, we describe how these nonleukocytic cells can perceive bacterial pathogens of bone to initiate the production of an array of immune regulatory molecules. This pattern of expression is one that could promote the recruitment of leukocytes to sites of bacterial challenge, initiate antigen-specific activation of infiltrating cells, and facilitate the development of cell-mediated host responses to intracellular pathogens of bone tissue, thereby identifying this cell type as a previously unappreciated component in host responses.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.