ReviewImmunologic research2004
C-reactive protein: an activator of innate immunity and a modulator of adaptive immunity.
Review in Immunologic research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
162 citing papers in PubMed, 8 syntheses or guidelines pooled it, 409 citations in OpenAlex.
- The association between C-reactive protein and coronary artery calcification: a systematic review and meta-analysis.BMC cardiovascular disorders · 2024Pooled it
- Serum C-reactive protein greater than 75 mg/dL as an early available laboratory predictor of severe COVID-19: A systematic review.Immunity, inflammation and disease · 2023Pooled it
- The Promising Role of Microbiome Therapy on Biomarkers of Inflammation and Oxidative Stress in Type 2 Diabetes: A Systematic and Narrative Review.Frontiers in nutrition · 2022Pooled it
- C-reactive protein as an effector molecule in Covid-19 pathogenesis.Reviews in medical virology · 2021Pooled it
- Association between Circulating Irisin and C-Reactive Protein Levels: A Systematic Review and Meta-Analysis.Endocrinology and metabolism (Seoul, Korea) · 2019Pooled it
- C-reactive Protein -717A>G and -286C>T>A Gene Polymorphism and Ischemic Stroke.Chinese medical journal · 2015Pooled it
- Atorvastatin Treatment for Atrial Fibrillation Reduces Serum High-Sensitivity C-Reactive Protein Levels.BioMed research international · 2015Pooled it
- Novel risk factors for cardiovascular disease in rheumatoid arthritis.Immunologic research · 2013Pooled it
- The effects of EPA and DHA enriched fish oil on nutritional and immunological markers of treatment naïve breast cancer patients: a randomized double-blind controlled trial.Nutrition journal · 2017Trial
- Comparison of tumour-based (Petersen Index) and inflammation-based (Glasgow Prognostic Score) scoring systems in patients undergoing curative resection for colon cancer.British journal of cancer · 2009Trial
- Clinical characteristics of bloodstream infections in the patients receiving anti-IL-6 receptor antibody.Infection · 2026Article
- Even mild elevations of C-reactive protein levels predict long-term prognosis in heart failure with mildly reduced ejection fraction.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Predictive Value of C-reactive Protein for Hospitalization and Mortality Among People With Advanced HIV Disease in Uganda Receiving the World Health Organization-recommended Package of Care.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Selected inflammatory markers in uterine and peripheral blood of bitches with pyometra.Journal of veterinary research · 2026Article
- "CRP-first" algorithm to guide imaging in suspected renal colic: a retrospective UK cohort study.Emergency radiology · 2025Article
- Is the C reactive protein/albumin ratio a good tool for retinal vein occlusion?BMC ophthalmology · 2025Article
- A study on the effect of COVID-19 infection on the serum concentration of antipsychotic drugs.BMC psychiatry · 2025Article
- A Wearable In-Pad Diagnostic for the Detection of Disease Biomarkers in Menstruation Blood.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Irisin Concentrations in Children and Adolescent Cancer Survivors and Their Relation to Metabolic, Bone, and Reproductive Profile: A Pilot Case-Control Study.Journal of clinical medicine · 2025Article
- Physical activity affects DNA methylation-derived inflammation markers in a community-based Parkinson's disease study.Brain, behavior, & immunity - health · 2025Article
102 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
C-reactive protein (CRP) is an acute-phase serum protein and a member of the pentraxin protein family. Its host defense functions predate the adaptive immune system by millions of years. Our current understanding of CRP interactions with complement and with Fcgamma receptors (FcgammaR) have led to an increased appreciation of the regulatory role of CRP in inflammation and autoimmunity. This review outlines the role of CRP in infection, inflammation, and autoimmune disease. We provide a description of recent studies, which suggest that CRP acts through FcgammaR to reduce inflammation and protect from certain autoimmune diseases. A general description of the proposed function of CRP is provided as a framework for future investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.