ArticleEnvironmental health perspectives2004
In vivo imaging of activated estrogen receptors in utero by estrogens and bisphenol A.
Article in Environmental health perspectives, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- Endocrine-Disrupting Chemicals, Hypothalamic Inflammation and Reproductive Outcomes: A Review of the Literature.International journal of molecular sciences · 2024Review
- The impacts of intrauterine Bisphenol A exposure on pregnancy and expression of miRNAs related to heart development and diseases in animal model.Scientific reports · 2020Article
- Decreased Capacity for Sperm Production Induced by Perinatal Bisphenol A Exposure Is Associated with an Increased Inflammatory Response in the Offspring of C57BL/6 Male Mice.International journal of environmental research and public health · 2018Article
- Association of urinary concentrations of bisphenol A and phthalate metabolites with risk of type 2 diabetes: a prospective investigation in the Nurses' Health Study (NHS) and NHSII cohorts.Environmental health perspectives · 2014Article
- Differential estrogenic actions of endocrine-disrupting chemicals bisphenol A, bisphenol AF, and zearalenone through estrogen receptor α and β in vitro.Environmental health perspectives · 2012Article
- Actions of estrogens and endocrine disrupting chemicals on human prostate stem/progenitor cells and prostate cancer risk.Molecular and cellular endocrinology · 2012Review
- Endocrine-disrupting chemicals: associated disorders and mechanisms of action.Journal of environmental and public health · 2012Review
- Endocrine-disrupting chemicals: an Endocrine Society scientific statement.Endocrine reviews · 2009Review
- Endocrine disruptors and prostate cancer risk.Endocrine-related cancer · 2008Review
- In vivo imaging of molecular targets and their function in endocrinology.Journal of molecular endocrinology · 2008Review
- Exposure to environmentally relevant doses of the xenoestrogen bisphenol-A alters development of the fetal mouse mammary gland.Endocrinology · 2007Article
- Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon.BMC biotechnology · 2006Article
- An evaluation of evidence for the carcinogenic activity of bisphenol A.Reproductive toxicology (Elmsford, N.Y.)Review
- In vivo effects of bisphenol A in laboratory rodent studies.Reproductive toxicology (Elmsford, N.Y.)Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environmental estrogens are of particular concern when exposure occurs during embryonic development. Although there are good models to study estrogenic activity of chemicals in adult animals, developmental exposure is much more difficult to test. The weak estrogenic activity of the environmental estrogen bisphenol A (BPA) in embryos is controversial. We have recently generated transgenic mice that carry a reporter construct with estrogen-responsive elements coupled to luciferase. We show that, using this in vivo model in combination with the IVIS imaging system, activation of estrogen receptors (ERs) by maternally applied BPA and other estrogens can be detected in living embryos in utero. Eight hours after exposure to 1 mg/kg BPA, ER transactivation could be significantly induced in the embryos. This was more potent than would be estimated from in vitro assays, although its intrinsic activity is still lower than that of diethylstilbestrol and 17beta-estradiol dipropionate. On the basis of these results, we conclude that the estrogenic potency of BPA estimated using in vitro assays might underestimate its estrogenic potential in embryos.
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Registered trials
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