ReviewPaediatric respiratory reviews2004
Clinical picture, diagnosis, treatment and outcome of severe acute respiratory syndrome (SARS) in children.
Review in Paediatric respiratory reviews, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparison of confirmed COVID-19 with SARS and MERS cases - Clinical characteristics, laboratory findings, radiographic signs and outcomes: A systematic review and meta-analysis.Reviews in medical virology · 2020Pooled it
- COVID-19 versus SARS: A comparative review.Journal of infection and public health · 2021Review
- Management of Coronavirus Disease 2019 (COVID-19) Pandemic: From Diagnosis to Treatment Strategies.Advanced therapeutics · 2021Review
- Coronavirus infections in children: from SARS and MERS to COVID-19, a narrative review of epidemiological and clinical features.Acta bio-medica : Atenei Parmensis · 2020Review
- Middle East Respiratory Syndrome Coronavirus and Severe Acute Respiratory Syndrome Coronavirus.Seminars in respiratory and critical care medicine · 2020Review
- Letter: Neurological Implications of COVID-19 and Lessons Learned From Prior Epidemics and Pandemics.Neurosurgery · 2020Article
- Immunopathogenesis of COVID-19 and early immunomodulators.Clinical and experimental pediatrics · 2020Article
- Clinical characteristics of COVID-19 in children: Are they similar to those of SARS?Pediatric pulmonology · 2020Review
- Clinical Characteristics of Children with Coronavirus Disease 2019 in Hubei, China.Current medical science · 2020Article
- Differences in Clinical and Imaging Presentation of Pediatric Patients with COVID-19 in Comparison with Adults.Radiology. Cardiothoracic imaging · 2020Article
- Comprehensive Analysis of Severe Viral Infections of Respiratory Tract admitted to PICUs during the Winter Season in Turkey.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2019Article
- Challenges presented by MERS corona virus, and SARS corona virus to global health.Saudi journal of biological sciences · 2016Review
- Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Distinct severe acute respiratory syndrome coronavirus-induced acute lung injury pathways in two different nonhuman primate species.Journal of virology · 2011Article
- Exacerbated innate host response to SARS-CoV in aged non-human primates.PLoS pathogens · 2010Article
- Effects of coronavirus infections in children.Emerging infectious diseases · 2010Article
- Unraveling the complexities of the interferon response during SARS-CoV infection.Future virology · 2009Article
- SARS-CoV replication and pathogenesis in an in vitro model of the human conducting airway epithelium.Virus research · 2008Review
- Functional genomics highlights differential induction of antiviral pathways in the lungs of SARS-CoV-infected macaques.PLoS pathogens · 2007Article
- Bird flu: lessons from SARS.Paediatric respiratory reviews · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Children are susceptible to infection by SARS-associated coronavirus (SARS-CoV) but the clinical picture of SARS is milder than in adults. Teenagers resemble adults in presentation and disease progression and may develop severe illness requiring intensive care and assisted ventilation. Fever, malaise, cough, coryza, chills or rigor, sputum production, headache, myalgia, leucopaenia, lymphopaenia, thrombocytopaenia, mildly prolonged activated partial thromboplastin times and elevated lactate dehydrogenase levels are common presenting features. Radiographic findings are non-specific but high-resolution computed tomography of the thorax in clinically suspected cases may be an early diagnostic aid when initial chest radiographs appear normal. The improved reverse transcription-polymerase chain reaction (RT-PCR) assays are critical in the early diagnosis of SARS, with sensitivity approaching 80% in the first 3 days of illness when performed on nasopharyngeal aspirates, the preferred specimens. Absence of seroconversion to SARS-CoV beyond 28 days from disease onset generally excludes the diagnosis. The best treatment strategy for SARS among children remains to be determined. No case fatality has been reported in children and the short- to medium-term outcome appears to be good. The importance of continued monitoring for any long-term complications due to the disease or its empiric treatment, cannot be overemphasised.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.