ArticleAmerican journal of human genetics2005
Mapping of the major psoriasis-susceptibility locus (PSORS1) in a 70-Kb interval around the corneodesmosin gene (CDSN).
Article in American journal of human genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 60 citations in OpenAlex.
- HLA-C*06:02-independent, gender-related association of PSORS1C3 and PSORS1C1/CDSN single-nucleotide polymorphisms with risk and severity of psoriasis.Molecular genetics and genomics : MGG · 2018Trial
- The psoriasis-associated deletion of late cornified envelope genes LCE3B and LCE3C has been maintained under balancing selection since Human Denisovan divergence.BMC evolutionary biology · 2016Article
- Allele-specific network reveals combinatorial interaction that transcends small effects in psoriasis GWAS.PLoS computational biology · 2014Article
- HLA-C, DRB1 and DQB1 alleles involved in genetic predisposition to psoriasis vulgaris in the Slovak population.Folia microbiologica · 2013Article
- The genetics of psoriasis and psoriatic arthritis.Clinical reviews in allergy & immunology · 2013Review
- Protective effect of human endogenous retrovirus K dUTPase variants on psoriasis susceptibility.The Journal of investigative dermatology · 2012Article
- HLA Immune Function Genes in Autism.Autism research and treatment · 2012Article
- Multiple Loci within the major histocompatibility complex confer risk of psoriasis.PLoS genetics · 2009Article
- New insights into the pathogenesis and genetics of psoriatic arthritis.Nature clinical practice. Rheumatology · 2009Review
- Targeted deletion of the murine corneodesmosin gene delineates its essential role in skin and hair physiology.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- [Molecular genetic basis of predisposition to psoriasis].Genetika · 2008Review
- Fine mapping of the psoriasis susceptibility locus PSORS1 supports HLA-C as the susceptibility gene in the Han Chinese population.PLoS genetics · 2008Article
- A second major histocompatibility complex susceptibility locus for multiple sclerosis.Annals of neurology · 2007Article
- Global variation in copy number in the human genome.Nature · 2006Article
- Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene.American journal of human genetics · 2006Article
- Immunogenomics: molecular hide and seek.Human genomics · 2006Review
- Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCR.Human genetics · 2005Article
- Genetics of psoriasis and psoriatic arthritis.Indian journal of dermatologyArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous putative susceptibility loci have been described for psoriasis. Among the loci confirmed in the literature, PSORS1 (the major histocompatibility complex at 6p21.3) has the strongest effect. Recent studies have highlighted a 200-kb candidate region. However, this region has not been well delimited, mainly because of the strong linkage equilibrium among the associated alleles. To finely map PSORS1, we set up a study using 17 polymorphic markers in a 525-kb interval around the human leucocyte antigen C locus (HLA-C). The results uncovered five loci with alleles strongly associated with psoriasis (Sidak-corrected P [P(c)] values from 1.8 x 10(-7) to .003), all structured in a psoriasis-susceptibility haplotype (PSH). Subsequent analysis of extended haplotypes showed that the PSH was not only present on the traditional psoriasis-susceptibility extended haplotypes (HLA-Cw6-B57, HLA-Cw6-B37, and HLA-Cw6-B13) but also on a haplotype of Sardinian origin (HLA-Cw7-B58) found to be associated with psoriasis (Pc=.0009) because of an ancestral recombination with one of the susceptibility haplotypes carrying the HLA-Cw6 allele. Comparisons of the regions identical by descent among associated and nonassociated haplotypes highlighted a minimum region of 70 kb not recombinant with PSORS1, around the corneodesmosin (CDSN) gene.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.