ArticleSurgical endoscopy2005
Peritoneal pH during laparoscopy is dependent on ambient gas environment: helium and nitrous oxide do not cause peritoneal acidosis.
Article in Surgical endoscopy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- Luminal microbiota related to Crohn's disease recurrence after surgery.Gut microbes · 2020Trial
- Effects of propofol on the inflammatory response during robot-assisted laparoscopic radical prostatectomy: a prospective randomized controlled study.Scientific reports · 2019Trial
- Underneath Images and Robots, Looking Deeper into the Pneumoperitoneum: A Narrative Review.Journal of clinical medicine · 2024Review
- The "Dark Side" of Pneumoperitoneum and Laparoscopy.Minimally invasive surgery · 2021Review
- Optimizing working-space in laparoscopy: measuring the effect of mechanical bowel preparation in a porcine model.Surgical endoscopy · 2013Article
- Application of stereology to study the effects of pneumoperitoneum on peritoneum.Surgical endoscopy · 2011Article
- Effects of simulated carbon dioxide and helium peumoperitoneum on proliferation and apoptosis of gastric cancer cells.World journal of gastroenterology · 2008Article
- Peritoneal and systemic pH during pneumoperitoneum with CO2 and helium in a pig model.Surgical endoscopy · 2008Article
- A possible mechanism of peritoneal pH changes during carbon dioxide pneumoperitoneum.Surgical endoscopy · 2007Article
- Effect of acidosis on expression of mesothelial cell plasminogen activator inhibitor type-1.Surgical endoscopy · 2006Article
- Exposure to carbon dioxide and helium reduces in vitro proliferation of pediatric tumor cells.Pediatric surgery international · 2006Article
- Abdominal insufflation with CO2 causes peritoneal acidosis independent of systemic pH.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2005Article
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundLittle is know about the effects of different insufflation gases on peritoneal pH during laparoscopy. However, these changes may influence the intracellular signalling system, resulting in altered cell growth or adhesiveness. The aim of this study was to determine the effects of carbon dioxide (CO(2)), nitrous oxide (N(2)O), and helium (He) on parietal and visceral peritoneal pH. The effect of different intraabdominal pressures on parietal and visceral peritoneal pH was also examined.
methodsWe conducted both an ambient gas study and a pressure study. For the ambient gas study, 20 pigs were divided into the following four groups: (a) CO(2), (b) He, (c) N(2)O, and (d) abdominal wall lift (Lift) laparoscopy. Parietal and visceral peritoneal pH were measured at 15 min intervals for 180 min. For the pressure study, 15 pigs were divided into the following three groups: (a) CO(2), (b) He, (c) N(2)O laparoscopy. Baseline values were established for parietal and visceral peritoneal pH. Intraabdominal pressure was then increased stepwise at 1-mmHg intervals to 15 mmHg. After pressure was maintained for 15 min at each setting, parietal and visceral peritoneal pH were measured.
resultsAmbient gas environment was the major determinant of parietal peritoneal pH. Carbon dioxide caused parietal peritoneal acidosis. Helium, N(2)O, and Lift caused alkalotic parietal peritoneal pH. Intraabdominal pressure had a minor effect on parietal peritoneal pH. At higher intraabdominal pressure (12-15 vs 5-8 mmHg), CO(2) caused a slight decrease in parietal peritoneal pH, whereas N(2)O and He caused a slight increase in parietal peritoneal pH. Visceral peritoneal pH remained relatively unaffected during all studies.
conclusionsParietal peritoneal pH during laparoscopy was highly dependent on the ambient gas environment. The effect of intraabdominal pressure on parietal peritoneal pH was of minor significance. Carbon dioxide caused a slight worsening of parietal peritoneal acidosis at higher intraabdominal pressure, whereas, N(2)O, He, and Lift did not cause parietal peritoneal acidosis.
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