ArticleJournal of clinical microbiology2004
Carious dentine provides a habitat for a complex array of novel Prevotella-like bacteria.
Article in Journal of clinical microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Clinical efficacy and the antimicrobial potential of silver formulations in arresting dental caries: a systematic review.BMC oral health · 2020Pooled it
- Supragingival Plaque Microbial Signatures Between Radiation Related Caries and Common Caries.International dental journal · 2025Article
- Article
- A comprehensive review of the application of probiotics and postbiotics in oral health.Frontiers in cellular and infection microbiology · 2023Review
- Tongue Microbiota Composition and Dental Caries Experience in Primary School Children.mSphere · 2021Article
- Deep metagenomics examines the oral microbiome during dental caries, revealing novel taxa and co-occurrences with host molecules.Genome research · 2021Article
- Ethnic variation of oral microbiota in children.Scientific reports · 2020Article
- Epigenetic Approaches to the Treatment of Dental Pulp Inflammation and Repair: Opportunities and Obstacles.Frontiers in genetics · 2018Review
- Selective persistence of Propionibacterium species FMA5 following sealing of infected dentinal matrix.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Article
- Article
- Microbiome of Deep Dentinal Caries Lesions in Teeth with Symptomatic Irreversible Pulpitis.PloS one · 2016Article
- Investigating Oral Microbiome Profiles in Children with Cleft Lip and Palate for Prognosis of Alveolar Bone Grafting.PloS one · 2016Article
- A novel compound to maintain a healthy oral plaque ecology in vitro.Journal of oral microbiology · 2016Article
- Standardizing 25-hydroxyvitamin D values from the Canadian Health Measures Survey.The American journal of clinical nutrition · 2015Article
- Age-dependent changes in Porphyromonas gingivalis and Prevotella species/phylotypes in healthy gingiva and inflamed/diseased sub-gingival sites.Clinical oral investigations · 2015Article
- Comparison of bacterial culture and 16S rRNA community profiling by clonal analysis and pyrosequencing for the characterization of the dentine caries-associated microbiome.Frontiers in cellular and infection microbiology · 2014Article
- Identification of the microbiota in carious dentin lesions using 16S rRNA gene sequencing.PloS one · 2014Article
- pH gradient and distribution of streptococci, lactobacilli, prevotellae, and fusobacteria in carious dentine.Clinical oral investigations · 2014Article
- As-yet-uncultivated oral bacteria: breadth and association with oral and extra-oral diseases.Journal of oral microbiology · 2013Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous analysis of the microbiology of advanced caries by culture and real-time PCR emphasized the high incidence and abundance of gram-negative anaerobic species, particularly Prevotella-like bacteria. The diversity of Prevotella-like bacteria was further explored by analyzing pooled bacterial DNA from lesions of carious dentine. This was achieved by amplification of a region of the 16S ribosomal DNA with a Prevotella genus-specific forward primer and a universal bacterial reverse primer, followed by cloning and sequencing. Cultured Prevotella species commonly associated with oral tissues constituted only 12% of the Prevotella clones isolated from advanced carious lesions. The remaining 88% consisted of a diverse range of phylotypes. These included five clusters of previously recognized but uncultured oral Prevotella spp. and a major cluster containing Prevotella-like bacteria most closely related to uncharacterized rumen bacteria. Cluster-specific primers were designed, and the numbers of bacteria within clusters were quantified by real-time PCR, confirming the abundance of these organisms. The data indicated that advanced dental caries provides a unique environment for a complex array of novel and uncultured Prevotella and Prevotella-like bacteria which, in some cases, may dominate the diverse polymicrobial community associated with the disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.