ArticleJournal of clinical microbiology2004
Genetic diversity of human pathogenic members of the Fusarium oxysporum complex inferred from multilocus DNA sequence data and amplified fragment length polymorphism analyses: evidence for the recent dispersion of a geographically widespread clonal lineage and nosocomial origin.
Article in Journal of clinical microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.
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Who cites it
99 citing papers in PubMed.
- Virulence determinants of Fusarium oxysporum for clinical infections.PLoS pathogens · 2026Article
- Phylogenetic Diversity of Fusarium Species Complexes Causing Wilt in Watermelon and Melon in Korea.The plant pathology journal · 2026Article
- Towards a Phylogenomic Framework for theInternational journal of molecular sciences · 2026Article
- Genome assembly of a clinicalMicrobiology resource announcements · 2026Article
- Article
- FoTeRs: a novel family of telomere-associated retrotransposons in Fusarium oxysporum.Mobile DNA · 2025Article
- Host-specific adaptation inmBio · 2025Article
- Gap-free comparative genomics uncover virulence factors for Fusarium wilt of watermelons.PLoS pathogens · 2025Article
- From Morphology to Multi-Omics: A New Age of Fusarium Research.Pathogens (Basel, Switzerland) · 2025Review
- Novel amplified fragment length polymorphism (AFLP) markers for typing medically relevantFungal systematics and evolution · 2025Article
- Virulence ofbioRxiv : the preprint server for biology · 2025Article
- The Dual PathogenJournal of fungi (Basel, Switzerland) · 2025Review
- Diagnosis and management of invasive fungal infections due to non-Aspergillus moulds.The Journal of antimicrobial chemotherapy · 2025Review
- Molecular Tracking of Emerging Fusarium Species in Keratitis: F. veterinarium, F. contaminatum, and F. curvatum.Mycopathologia · 2025Article
- Genomic Insights intoPathogens (Basel, Switzerland) · 2024Article
- Molecular identification of Fusarium species in commercial vanilla and crop wild relatives in Colombia.Environmental microbiology reports · 2024Article
- Characterization and organization of telomeric-linked helicase (tlh) gene families in Fusarium oxysporum.Current genetics · 2024Article
- A gap-free genome assembly of Fusarium oxysporum f. sp. conglutinans, a vascular wilt pathogen.Scientific data · 2024Article
- Sources of Fungal Symbionts in the Microbiome of a Mobile Insect Host, Spodoptera frugiperda.Microbial ecology · 2023Article
- Loss of Phosphomannose Isomerase Impairs Growth, Perturbs Cell Wall Integrity, and Reduces Virulence ofJournal of fungi (Basel, Switzerland) · 2023Article
39 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fusarium oxysporum is a phylogenetically diverse monophyletic complex of filamentous ascomycetous fungi that are responsible for localized and disseminated life-threatening opportunistic infections in immunocompetent and severely neutropenic patients, respectively. Although members of this complex were isolated from patients during a pseudoepidemic in San Antonio, Tex., and from patients and the water system in a Houston, Tex., hospital during the 1990s, little is known about their genetic relatedness and population structure. This study was conducted to investigate the global genetic diversity and population biology of a comprehensive set of clinically important members of the F. oxysporum complex, focusing on the 33 isolates from patients at the San Antonio hospital and on strains isolated in the United States from the water systems of geographically distant hospitals in Texas, Maryland, and Washington, which were suspected as reservoirs of nosocomial fusariosis. In all, 18 environmental isolates and 88 isolates from patients spanning four continents were genotyped. The major finding of this study, based on concordant results from phylogenetic analyses of multilocus DNA sequence data and amplified fragment length polymorphisms, is that a recently dispersed, geographically widespread clonal lineage is responsible for over 70% of all clinical isolates investigated, including all of those associated with the pseudoepidemic in San Antonio. Moreover, strains of the clonal lineage recovered from patients were conclusively shown to genetically match those isolated from the hospital water systems of three U.S. hospitals, providing support for the hypothesis that hospitals may serve as a reservoir for nosocomial fusarial infections.
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