ArticleJournal of clinical microbiology2004
Multilocus microsatellite typing system for Penicillium marneffei reveals spatially structured populations.
Article in Journal of clinical microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- Investigating Clinical Issues by Genotyping of Medically Important Fungi: Why and How?Clinical microbiology reviews · 2017Review
- Use of Population Genetics to Assess the Ecology, Evolution, and Population Structure of Coccidioides.Emerging infectious diseases · 2016Article
- Role of Rhizomys pruinosus as a natural animal host of Penicillium marneffei in Guangdong, China.Microbial biotechnology · 2015Article
- Multilocus microsatellite markers for molecular typing of Candida tropicalis isolates.BMC microbiology · 2014Article
- Highly discriminatory variable-number tandem-repeat markers for genotyping of Trichophyton interdigitale strains.Journal of clinical microbiology · 2014Article
- The cryptic sexual strategies of human fungal pathogens.Nature reviews. Microbiology · 2014Review
- Multilocus microsatellite signature and identification of specific molecular markers for Leishmania aethiopica.Parasites & vectors · 2013Article
- Phylogenetic analysis reveals a high prevalence of Sporothrix brasiliensis in feline sporotrichosis outbreaks.PLoS neglected tropical diseases · 2013Article
- Clonality despite sex: the evolution of host-associated sexual neighborhoods in the pathogenic fungus Penicillium marneffei.PLoS pathogens · 2012Article
- Common reservoirs for Penicillium marneffei infection in humans and rodents, China.Emerging infectious diseases · 2011Article
- The evolution of sex: a perspective from the fungal kingdom.Microbiology and molecular biology reviews : MMBR · 2010Review
- Uneven distribution of mating types among genotypes of Candida glabrata isolates from clinical samples.Eukaryotic cell · 2009Article
- MP1 homologue-based multilocus sequence system for typing the pathogenic fungus Penicillium marneffei: a novel approach using lineage-specific genes.Journal of clinical microbiology · 2007Article
- Multiple-locus variable-number tandem-repeat analysis for rapid typing of Candida glabrata.Journal of clinical microbiology · 2007Article
- Nucleotide sequence-based analysis for determining the molecular epidemiology of Penicillium marneffei.Journal of clinical microbiology · 2006Article
- Molecular genotyping of Candida parapsilosis group I clinical isolates by analysis of polymorphic microsatellite markers.Journal of clinical microbiology · 2006Article
- Multilocus microsatellite typing as a new tool for discrimination of Leishmania infantum MON-1 strains.Journal of clinical microbiology · 2006Article
- Penicillium marneffei infection and recent advances in the epidemiology and molecular biology aspects.Clinical microbiology reviews · 2006Review
- Low effective dispersal of asexual genotypes in heterogeneous landscapes by the endemic pathogen Penicillium marneffei.PLoS pathogens · 2005Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
For eukaryotic pathogens that have low levels of genetic variation, multilocus microsatellite typing (MLMT) offers an accurate and reproducible method of characterizing genetic diversity. Here, we describe the application of an MLMT system to the emerging pathogenic fungus Penicillium marneffei. Isolates used for this study were those held in the culture collections of the Centraalbureau voor Schimmelcultures, Utrecht, The Netherlands, and the Chiang Mai University Department of Microbiology, Chang Mai, Thailand. High genetic diversity and extensive spatial structure were observed among clinical isolates, with the geographical area of origin for each isolate strongly correlating with the occurrence of two deeply divided clades. Within each clade, multilocus linkage associations were highly significant and could be explained by genetically differentiated populations or by an exclusively clonal reproductive mode, or both. Our results show that southeast Asian penicilliosis is caused by a fungus with a complex population genetic structure. Furthermore, this MLMT system generates digital data that can be easily queried against a centrally held database via the internet (http://pmarneffei.multilocus.net/); this provides a powerful epidemiological tool for analyzing the underlying parameters that are responsible for the emergence of P. marneffei in human immunodeficiency virus-positive populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.