ArticleJournal of clinical microbiology2004
Characterization of ancestral Mycobacterium tuberculosis by multiple genetic markers and proposal of genotyping strategy.
Article in Journal of clinical microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Genetic Diversity and Population Structure ofPathogens (Basel, Switzerland) · 2023Article
- Molecular Diversity ofJundishapur journal of microbiology · 2016Article
- Article
- African 2, a clonal complex of Mycobacterium bovis epidemiologically important in East Africa.Journal of bacteriology · 2011Article
- Audit and improve! Evaluation of a real-time probe-based PCR assay with internal control for the direct detection of Mycobacterium tuberculosis complex.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2011Article
- A conformal Bayesian network for classification of Mycobacterium tuberculosis complex lineages.BMC bioinformatics · 2010Article
- Polymorphic exact tandem repeat A (PETRA): a newly defined lineage of mycobacterium tuberculosis in israel originating predominantly in Sub-Saharan Africa.Journal of clinical microbiology · 2009Article
- Determination of Major Lineages of Mycobacterium tuberculosis Complex using Mycobacterial Interspersed Repetitive Units.Proceedings. IEEE International Conference on Bioinformatics and Biomedicine · 2009Article
- Models of deletion for visualizing bacterial variation: an application to tuberculosis spoligotypes.BMC bioinformatics · 2008Article
- Genomic interrogation of ancestral Mycobacterium tuberculosis from south India.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2008Article
- Characterization of Mycobacterium tuberculosis Central Asian Strain 1 using mycobacterial interspersed repetitive unit genotyping.BMC microbiology · 2007Article
- Spoligotype signatures in the Mycobacterium tuberculosis complex.Journal of clinical microbiology · 2007Article
- Predominance of ancestral lineages of Mycobacterium tuberculosis in India.Emerging infectious diseases · 2006Article
- ProtRepeatsDB: a database of amino acid repeats in genomes.BMC bioinformatics · 2006Article
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Authors and funding
10 authors.
Funding
Abstract
Sixty-eight ancestral Mycobacterium tuberculosis isolates were previously identified by using the tuberculosis-specific deletion 1 (TbD1) PCR and mycobacterial interspersed-repetitive-unit-variable-number tandem repeat (MIRU-VNTR) typing (Y. J. Sun, R. Bellamy, A. S. G. Lee, S. T. Ng, S. Ravindran, S.-Y. Wong, C. Locht, P. Supply, and N. I. Paton, J. Clin. Microbiol. 42:1986-1993, 2004). These TbD1(+) ancestral isolates were further characterized and typed in this study by IS6110 restriction fragment length polymorphism (RFLP) typing, VNTR typing using exact tandem repeats (VNTR-ETR), and spoligotyping of the direct-repeat region. To our knowledge, this is the first characterization of this genogroup by multiple genetic markers based on a fairly large sample size. In this genogroup, all spoligotypes were characterized by the absence of spacers 29 to 32 and 34. In addition, VNTR-ETR typing could add further resolution to the clustered isolates identified by MIRU-VNTR, and the combination of MIRU-VNTR and VNTR-ETR, called MIRU-ETR, showed the highest discriminatory power for these strains compared to IS6110 RFLP typing and spoligotyping alone. However, MIRU-ETR appeared to still cluster some probably epidemiologically unrelated strains, as judged by IS6110 RFLP divergence. Therefore, a typing strategy based on stepwise combination of MIRU-ETR and IS6110 RFLP is proposed to achieve maximal discrimination for unrelated TbD1(+) strains. This typing strategy may be useful in areas where TbD1(+) ancestral strains are prevalent.
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