ArticleJournal of clinical microbiology2004
Distribution of putative adhesins in different seropathotypes of Shiga toxin-producing Escherichia coli.
Article in Journal of clinical microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed, 177 citations in OpenAlex.
- Distribution of putative adhesins in Shiga toxin-producing Escherichia coli (STEC) strains isolated from different sources in Chile.Epidemiology and infection · 2007Trial
- Isolation and Characterization Through Whole-Genome Sequencing of STEC Strains from Free-Ranging Red Deer.Veterinary sciences · 2025Article
- Comparative genomics of Shiga toxin-producingFrontiers in veterinary science · 2025Article
- Whole genome sequencing analysis of enteropathogenicJournal of veterinary science · 2025Article
- Shiga Toxin-ProducingMicroorganisms · 2024Article
- Transcription levels of hes and their involvement in the biofilm formation of Shiga toxin-producing Escherichia coli O91.Veterinary research communications · 2024Article
- Prevalence and Molecular Characterization of Shiga Toxin-ProducingPathogens (Basel, Switzerland) · 2023Article
- Free-ranging red deer (Cervus elaphus) as carriers of potentially zoonotic Shiga toxin-producing Escherichia coli.Transboundary and emerging diseases · 2022Article
- Prevalence of Shiga toxin-producing Escherichia coli in Yezo sika deer (Cervus nippon yesoensis) in the Tokachi sub-prefecture of Hokkaido, Japan.The Journal of veterinary medical science · 2022Article
- The Importance of Shiga Toxin-ProducingMicroorganisms · 2022Article
- Prevalence, Antimicrobial Resistance, and Whole Genome Sequencing Analysis of Shiga Toxin-ProducingToxins · 2022Article
- ABToxins · 2022Review
- High prevalence and pathogenic potential of Shiga toxin-producingCurrent research in food science · 2022Article
- Virulence Profiling and Molecular Typing of Shiga Toxin-ProducingMicroorganisms · 2020Article
- Identification and detection ofHeliyon · 2019Article
- High prevalence of non-O157 Shiga toxin-producing Escherichia coli in beef cattle detected by combining four selective agars.BMC microbiology · 2019Article
- Escherichia coli H-Genotyping PCR: a Complete and Practical Platform for Molecular H Typing.Journal of clinical microbiology · 2018Article
- Shiga toxin 2 translocation across intestinal epithelium is linked to virulence of Shiga toxin-producing Escherichia coli in humans.Microbiology (Reading, England) · 2018Article
- Pathogenicity Islands Distribution in Non-O157 Shiga Toxin-Producing Escherichia coli (STEC).Genes · 2018Article
- Detection and Characterization of Enteropathogenic and Shiga Toxin-ProducingFrontiers in microbiology · 2018Article
16 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The distribution of eight putative adhesins that are not encoded in the locus for enterocyte effacement (LEE) in 139 Shiga toxin-producing Escherichia coli (STEC) of different serotypes was investigated by PCR. Five of the adhesins (Iha, Efa1, LPF(O157/OI-141), LPF(O157/OI-154), and LPF(O113)) are encoded in regions corresponding to genomic O islands of E. coli EDL933, while the other three adhesins have been reported to be encoded in the STEC megaplasmid of various serotypes (ToxB [O157:H7], Saa [O113:H21], and Sfp [O157:NM]). STEC strains were isolated from humans (n = 54), animals (n = 52), and food (n = 33). They were classified into five seropathotypes (A through E) based on the reported occurrence of STEC serotypes in human disease, in outbreaks, and in the hemolytic-uremic syndrome (M. A. Karmali, M. Mascarenhas, S. Shen, K. Ziebell, S. Johnson, R. Reid-Smith, J. Isaac-Renton, C. Clark, K. Rahn, and J. B. Kaper, J. Clin. Microbiol. 41:4930-4940, 2003). The most prevalent adhesin was that encoded by the iha gene (91%; 127 of 139 strains), which was distributed in all seropathotypes. toxB and efa1 were present mainly in strains of seropathotypes A and B, which were LEE positive. saa was present only in strains of seropathotypes C, D, and E, which were LEE negative. Two fimbrial genes, lpfA(O157/OI-141) and lpfA(O157/OI-154), were strongly associated with seropathotype A. The fimbrial gene lpfA(O113) was present in all seropathotypes except for seropathotype A, while sfpA was not present in any of the strains studied. The distribution of STEC adhesins depends mainly on serotypes and not on the source of isolation. Seropathotype A, which is associated with severe disease and frequently is involved in outbreaks, possesses a unique adhesin profile which is not present in the other seropathotypes. The wide distribution of iha in STEC strains suggested that it could be a candidate for vaccine development.
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