ArticleJournal of clinical microbiology2004
Microsatellite mapping of Mycobacterium leprae populations in infected humans.
Article in Journal of clinical microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 38 citations in OpenAlex.
- Development and evaluation of a droplet digital PCR assay for the diagnosis of paucibacillary leprosy in skin biopsy specimens.PLoS neglected tropical diseases · 2019Article
- Multiple strain infection of Mycobacterium leprae in a family having 4 patients: A study employing short tandem repeats.PloS one · 2019Article
- Genotyping comparison of Mycobacterium leprae isolates by VNTR analysis from nasal samples in a Brazilian endemic region.Pathogens and global health · 2018Article
- Transmission of leprosy in Qiubei County, Yunnan, China: insights from an 8-year molecular epidemiology investigation.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2011Article
- Mycobacterium leprae: genes, pseudogenes and genetic diversity.Future microbiology · 2011Review
- Comparative genomic and phylogeographic analysis of Mycobacterium leprae.Nature genetics · 2009Article
- Population-based molecular epidemiology of leprosy in Cebu, Philippines.Journal of clinical microbiology · 2009Article
- Rapid variable-number tandem-repeat genotyping for Mycobacterium leprae clinical specimens.Journal of clinical microbiology · 2009Article
- Are variable-number tandem repeats appropriate for genotyping Mycobacterium leprae?Journal of clinical microbiology · 2008Article
- Use of short tandem repeat sequences to study Mycobacterium leprae in leprosy patients in Malawi and India.PLoS neglected tropical diseases · 2008Article
- Identification and distribution of Mycobacterium leprae genotypes in a region of high leprosy prevalence in China: a 3-year molecular epidemiological study.Journal of clinical microbiology · 2007Article
- Isothermal amplification and molecular typing of the obligate intracellular pathogen Mycobacterium leprae isolated from tissues of unknown origins.Journal of clinical microbiology · 2006Article
- Diversity of potential short tandem repeats in Mycobacterium leprae and application for molecular typing.Journal of clinical microbiology · 2005Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate genetic diversity in a bacterial population, we measured the copy numbers of simple sequence repeats, or microsatellites, in Mycobacterium leprae from patients living in and around Hyderabad, India. Three microsatellite loci containing trinucleotide or dinucleotide repeats were amplified from infected tissues, and the copy numbers were established by sequence analysis. Extensive diversity was observed in a cross-sectional survey of 33 patients, but closely related profiles were found for members of a multicase family likely to share a common transmission source. Sampling of multiple tissues from single individuals demonstrated identical microsatellite profiles in the skin, nasal cavity, and bloodstream but revealed differences at one or more loci for M. leprae present in nerves. Microsatellite mapping of M. leprae represents a useful tool for tracking short transmission chains. Comparison of skin and nerve lesions suggests that the evolution of disease within an individual involves the expansion of multiple distinct subpopulations of M. leprae.
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