ArticleApplied and environmental microbiology2004
Morphotypic conversion in Listeria monocytogenes biofilm formation: biological significance of rough colony isolates.
Article in Applied and environmental microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed.
- Review
- Proteomic analysis reveals the temperature-dependent presence of extracytoplasmic peptidases in the biofilm exoproteome of Listeria monocytogenes EGD-e.Journal of microbiology (Seoul, Korea) · 2020Article
- Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus.Nature communications · 2019Article
- Efficacy of chemical sanitizers againstFood science and biotechnology · 2019Article
- The Novel Internalins InlP1 and InlP4 and the Internalin-Like Protein InlP3 Enhance the Pathogenicity ofFrontiers in microbiology · 2019Article
- Impact of Nutrient Restriction on the Structure ofFrontiers in microbiology · 2017Article
- Competing for Iron: Duplication and Amplification of the isd Locus in Staphylococcus lugdunensis HKU09-01 Provides a Competitive Advantage to Overcome Nutritional Limitation.PLoS genetics · 2016Article
- A prl mutation in SecY suppresses secretion and virulence defects of Listeria monocytogenes secA2 mutants.Journal of bacteriology · 2015Article
- Article
- DNase-Sensitive and -Resistant Modes of Biofilm Formation by Listeria monocytogenes.Frontiers in microbiology · 2015Article
- SecA: a potential antimicrobial target.Future medicinal chemistry · 2015Review
- Intra- and inter-species interactions within biofilms of important foodborne bacterial pathogens.Frontiers in microbiology · 2015Review
- LysPGS formation in Listeria monocytogenes has broad roles in maintaining membrane integrity beyond antimicrobial peptide resistance.Virulence · 2014Article
- Biofilm-forming bacteria with varying tolerance to peracetic acid from a paper machine.Journal of industrial microbiology & biotechnology · 2011Article
- Directed evolution and targeted mutagenesis to murinize Listeria monocytogenes internalin A for enhanced infectivity in the murine oral infection model.BMC microbiology · 2010Article
- Hydrogen peroxide linked to lysine oxidase activity facilitates biofilm differentiation and dispersal in several gram-negative bacteria.Journal of bacteriology · 2008Article
- Listeria monocytogenes EGD-e biofilms: no mushrooms but a network of knitted chains.Applied and environmental microbiology · 2008Article
- Tools for functional postgenomic analysis of listeria monocytogenes.Applied and environmental microbiology · 2008Article
- Development of multiple strain competitive index assays for Listeria monocytogenes using pIMC; a new site-specific integrative vector.BMC microbiology · 2008Article
- Phenotypic diversification and adaptation of Serratia marcescens MG1 biofilm-derived morphotypes.Journal of bacteriology · 2007Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adherence to a stainless steel surface selected isolates of Listeria monocytogenes with enhanced surface colonization abilities and a change in phenotype from the common smooth colony morphology to a succession of rough colony morphotypes. Growth in broth culture of the best-adapted, surface-colonizing rough colony morphotype gave a smooth colony revertant. Comparative analysis revealed that the smooth and rough variants had similar phenotypic and biochemical characteristics (e.g., identical growth rates and tolerances to antibiotics and environmental stressors). Rough colony isolates, however, failed to coordinate motility or induce autolysis. The defect in autolysis of rough colony isolates, which involved impaired cellular localization of several peptidoglycan-degrading enzymes, including cell wall hydrolase A (CwhA), suggested a link to a secretory pathway defect. The genetic basis for the impairment was studied at the level of the accessory secretory pathway component SecA2. DNA sequencing of the secA2 gene in smooth and rough colony isolates found no mutations in the coding or promoter regions. Analysis of SecA2 expression with an integrated secA2-FLAG tag construct found the protein to be upregulated in the rough and revertant backgrounds compared to the parental smooth colony isolate. A compensatory mechanism involving the SecA2 secretion pathway components is postulated to control smooth to rough interconversion of L. monocytogenes. Such phenotypic variation may enhance the ability of this opportunistic pathogen to colonize environments as diverse as processing surfaces, food products, and animal hosts.
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