ArticleApplied and environmental microbiology2004
Dynamics of multiple lin gene expression in Sphingomonas paucimobilis B90A in response to different hexachlorocyclohexane isomers.
Article in Applied and environmental microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Insights on Anabaena sp. PCC 7120 Responses to HCH Isomers: Tolerance, Degradation, and Dynamics on Potential lin Genes Expression.MicrobiologyOpen · 2025Article
- Assessing HCH isomer uptake in Alnus glutinosa: implications for phytoremediation and microbial response.Scientific reports · 2024Article
- Responses of Anabaena sp. PCC7120 to lindane: Physiological effects and differential expression of potential lin genes.MicrobiologyOpen · 2023Article
- Comparative proteomics unravelled the hexachlorocyclohexane (HCH) isomers specific responses in an archetypical HCH degrading bacterium Sphingobium indicum B90A.Environmental science and pollution research international · 2021Article
- Towards the Response Threshold forApplied and environmental microbiology · 2018Article
- Genome Organization of Sphingobium indicum B90A: An Archetypal Hexachlorocyclohexane (HCH) Degrading Genotype.Genome biology and evolution · 2017Article
- Insights into Ongoing Evolution of the Hexachlorocyclohexane Catabolic Pathway from Comparative Genomics of Ten Sphingomonadaceae Strains.G3 (Bethesda, Md.) · 2015Article
- Comparative genomic analysis of nine Sphingobium strains: insights into their evolution and hexachlorocyclohexane (HCH) degradation pathways.BMC genomics · 2014Article
- Reconstructing an ancestral genotype of two hexachlorocyclohexane-degrading Sphingobium species using metagenomic sequence data.The ISME journal · 2014Article
- Evaluation of hexachlorocyclohexane contamination from the last lindane production plant operating in India.Environmental science and pollution research international · 2011Article
- The evolution of new enzyme function: lessons from xenobiotic metabolizing bacteria versus insecticide-resistant insects.Evolutionary applications · 2011Article
- Biochemistry of microbial degradation of hexachlorocyclohexane and prospects for bioremediation.Microbiology and molecular biology reviews : MMBR · 2010Review
- Pseudomonas sp. to Sphingobium indicum: a journey of microbial degradation and bioremediation of Hexachlorocyclohexane.Indian journal of microbiology · 2008Article
- Haloalkane dehalogenase LinB is responsible for beta- and delta-hexachlorocyclohexane transformation in Sphingobium indicum B90A.Applied and environmental microbiology · 2006Article
- Enantioselective transformation of alpha-hexachlorocyclohexane by the dehydrochlorinases LinA1 and LinA2 from the soil bacterium Sphingomonas paucimobilis B90A.Applied and environmental microbiology · 2005Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sphingomonas paucimobilis B90A is able to degrade the alpha-, beta-, gamma-, and delta-isomers of hexachlorocyclohexane (HCH). It contains the genes linA, linB, linC, linD, linE, and linR, which have been implicated in HCH degradation. In this study, dynamic expression of the lin genes was measured in chemostat-grown S. paucimobilis B90A by RNA dot blot hybridization and real-time reverse transcriptase PCR upon exposure to a pulse of different HCH isomers. Irrespective of the addition of HCH, linA, linB, and linC were all expressed constitutively. In contrast, linD and linE were induced with alpha-HCH (2 mg/liter) and gamma-HCH (7 mg/liter). A sharp increase in mRNA levels for linD and linE was observed from 10 to 45 min after the addition of alpha- or gamma-HCH. Induction of linD and linE was not detectable upon the addition of 0.7 mg of gamma-HCH per liter, although the compound was degraded by the cells. The addition of beta-HCH (5 mg/liter) or delta-HCH (20 mg/liter) did not lead to linE and linD induction, despite the fact that 50% of the compounds were degraded. This suggests that degradation of beta- and delta-HCH proceeds by a different pathway than that of alpha- and gamma-HCH.
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