ArticleProceedings of the National Academy of Sciences of the United States of America2004
A screen for genes that suppress loss of contact inhibition: identification of ING4 as a candidate tumor suppressor gene in human cancer.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed, 135 citations in OpenAlex.
- The Effect of Circumscribed Exposure to the Pan-Aurora Kinase Inhibitor VX-680 on Proliferating Euploid Cells.International journal of molecular sciences · 2022Article
- Review
- Enhanced effect of recombinant adenoviruses co-expression of ING4 and OSM on anti-tumour activity of laryngeal cancer.Journal of cellular and molecular medicine · 2022Article
- ING Proteins: Tumour Suppressors or Oncoproteins.Cancers · 2021Review
- Variation in the life history strategy underlies functional diversity of tumors.National science review · 2021Article
- A high-content screen identifies the vulnerability of MYC-overexpressing cells to dimethylfasudil.PloS one · 2021Article
- Close Encounters of the Cell Kind: The Impact of Contact Inhibition on Tumour Growth and Cancer Models.Bulletin of mathematical biology · 2020Article
- Identification of the inhibitor of growth protein 4 (ING4) as a potential target in prostate cancer therapy.Molecular and cellular biochemistry · 2020Article
- The essential role of tumor suppressor geneBioscience reports · 2019Review
- Enhanced anti-melanoma efficacy of interferon α-2b via overexpression of ING4 by enhanced Fas/FasL-mediated apoptosis.Oncology letters · 2018Article
- Article
- Overexpression of Inhibitor of Growth 4 Enhances Radiosensitivity in Non-Small Cell Lung Cancer Cell Line SPC-A1.Technology in cancer research & treatment · 2017Article
- Association between the expression of inhibitor of growth family member 4 and the progression of clear cell renal carcinoma.Oncology letters · 2017Article
- A 22q11.2 amplification in the region encoding microRNA-650 correlates with the epithelial to mesenchymal transition in breast cancer primary cultures of Mexican patients.International journal of oncology · 2017Article
- INGs are potential drug targets for cancer.Journal of cancer research and clinical oncology · 2017Review
- The association of inhibitor of Growth 4 with its prognostic value in osteogenic sarcoma.International journal of clinical and experimental pathology · 2017Article
- Mechanism of Histone H3K4me3 Recognition by the Plant Homeodomain of Inhibitor of Growth 3.The Journal of biological chemistry · 2016Article
- Combinatorial strategies based on CRAd-IL24 and CRAd-ING4 virotherapy with anti-angiogenesis treatment for ovarian cancer.Journal of ovarian research · 2016Article
- Inhibitor of growth-4 is a potential target for cancer therapy.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- Reduced expression and prognostic implication of inhibitor of growth 4 in human osteosarcoma.Oncology letters · 2016Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
We have devised a screen for genes that suppress the loss of contact inhibition elicited by overexpression of the protooncogene MYCN. The initial application of this screen detected nine distinctive suppressors within a representative human cDNA library. One of these genes was ING4, a potential tumor suppressor gene that maps to human chromosome 12p13. Ectopic expression of ING4 suppressed the loss of contact inhibition elicited by either MYCN or MYC but had no direct effect on cellular proliferation. Pursuing the possibility that ING4 might be a tumor suppressor gene, we found inactivating mutations in ING4 transcripts from various human cancer cell lines. In addition, we used comparative genomic hybridization to detect deletion of the ING4 locus in 10-20% of human breast cancer cell lines and primary breast tumors. Ectopic expression of ING4 attenuated the growth of T47D human breast cancer cells in soft agar. We conclude that ING4 is a strong candidate as a tumor suppressor gene.
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