ArticleThe Journal of physiology2005
Recruitment of motor neuronal persistent inward currents shapes withdrawal reflexes in the frog.
Article in The Journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Use of cyproheptadine hydrochloride (HCl) to reduce neuromuscular hypertonicity in stroke survivors: A Randomized Trial: Reducing Hypertonicity in Stroke.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2022Trial
- Serotonergic Modulation of Persistent Inward Currents in Serotonergic Neurons of Medulla in ePet-EYFP Mice.Frontiers in neural circuits · 2021Article
- Conditional Bistability, a Generic Cellular Mnemonic Mechanism for Robust and Flexible Working Memory Computations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Turtle Flexion Reflex Motor Patterns Show Windup, Mediated Partly by L-type Calcium Channels.Frontiers in neural circuits · 2017Article
- Sodium-mediated plateau potentials in lumbar motoneurons of neonatal rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Exploring the central modulation hypothesis: do ancient memory mechanisms underlie the pathophysiology of trigger points?Current pain and headache reports · 2013Review
- Serotonin spillover onto the axon initial segment of motoneurons induces central fatigue by inhibiting action potential initiation.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Neuronal intrinsic properties shape naturally evoked sensory inputs in the dorsal horn of the spinal cord.Frontiers in cellular neuroscience · 2013Article
- Somato-dendritic morphology and dendritic signal transfer properties differentiate between fore- and hindlimb innervating motoneurons in the frog Rana esculenta.BMC neuroscience · 2012Article
- The activity of leech motoneurons during motor patterns is regulated by intrinsic properties and synaptic inputs.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2012Article
- L-type Ca2+ current in frog tectal recurrent neurons determines the NMDA receptor activation on efferent neuron.Experimental brain research · 2009Article
- Persistent responses to brief stimuli: feedback excitation among brainstem neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Evaluation of plateau-potential-mediated 'warm up' in human motor units.The Journal of physiology · 2006Article
- Synaptic release of serotonin induced by stimulation of the raphe nucleus promotes plateau potentials in spinal motoneurons of the adult turtle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The details of behaviour are determined by the interplay of synaptic connectivity within neuronal circuitry and the intrinsic membrane properties of individual neurones. One particularly dramatic intrinsic property displayed by neurones in many regions of the nervous system is membrane potential bistability, in which transient excitation of a neurone results in a persistent depolarization outlasting the initial excitation. Here we characterize the contribution of such intrinsic bistability, also referred to as plateau properties and mediated by persistent inward currents (PICs), in spinal motor neurones to the production of withdrawal behaviours in the frog. We performed experiments on the isolated frog spinal cord with attached hindlimb. This preparation allowed the simultaneous monitoring of muscle activations during motor behaviour and intracellular neuronal recordings. We found that PICs, following their potentiation by serotonin (5-HT), are recruited and contribute to the production of withdrawal behaviours. These properties conferred a voltage-dependent prolongation to the duration of motor neuronal activity. Consistent with this potentiation of motor neuronal PICs, 5-HT also increased the duration of evoked muscle activations. This behavioural potentiation, as well as the expression of PICs in individual neurones, was reduced following antagonism of L-type Ca(2+) channels. These results demonstrate that PICs in motor neurones can be recruited during the production of behaviour and play a role in specifying the temporal details of motor output.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.