ArticleWorld journal of gastroenterology2004
Expression of Dnmt1, demethylase, MeCP2 and methylation of tumor-related genes in human gastric cancer.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- MeCP2 functions as a DNA methylation reader in immune homeostasis and cancer.Frontiers in epigenetics and epigenomics · 2026Review
- Review
- The Epigenetic Reader Methyl-CpG-Binding Protein 2 (MeCP2) Is an Emerging Oncogene in Cancer Biology.Cancers · 2023Review
- The genome-wide mutational consequences of DNA hypomethylation.Scientific reports · 2023Article
- Epigenomic reprogramming in iAs-mediated carcinogenesis.Advances in pharmacology (San Diego, Calif.) · 2023Article
- TIPE2 inhibits GC via regulation of cell proliferation, apoptosis and inflammation.Oncology reports · 2018Article
- Expression of interleukin 1β in gastric cancer tissue and its effects on gastric cancer.OncoTargets and therapy · 2016Article
- Promoter region hypermethylation and mRNA expression of MGMT and p16 genes in tissue and blood samples of human premalignant oral lesions and oral squamous cell carcinoma.BioMed research international · 2014Article
- Expression of DNMTs and MBD2 in GIST.Biomedical reports · 2013Article
- DNA and histone methylation in gastric carcinogenesis.World journal of gastroenterology · 2013Review
- Human GMDS gene fragment hypermethylation in chronic high level of arsenic exposure with and without arsenic induced cancer.SpringerPlus · 2013Article
- Article
- Association of self-DNA mediated TLR9-related gene, DNA methyltransferase, and cytokeratin protein expression alterations in HT29-cells to DNA fragment length and methylation status.TheScientificWorldJournal · 2013Article
- microRNA-450a targets DNA methyltransferase 3a in hepatocellular carcinoma.Experimental and therapeutic medicine · 2011Article
- MicroRNA-143 targets DNA methyltransferases 3A in colorectal cancer.British journal of cancer · 2009Article
- Article
- MYC and gastric adenocarcinoma carcinogenesis.World journal of gastroenterology · 2008Review
- The expression and clinical significance of DNA methyltransferase proteins in human gastric cancer.Digestive diseases and sciences · 2008Article
- Epigenetic silencing contributes to the loss of BRMS1 expression in breast cancer.Clinical & experimental metastasis · 2008Article
- Epigenetic effects of ethanol on liver and gastrointestinal injury.World journal of gastroenterology · 2006Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo explore the effect of DNA methyltransferase, demethylase and methyl-CpG binding protein MeCP2 on the expressions and methylation of hMSH2 and proto-oncogene in human gastric cancer.
methodsPaired samples of primary gastric cancer and corresponding para-cancerous, non-cancerous gastric mucosae were obtained from surgically resected specimens of 28 patients. Transcription levels of Dnmt1, mbd2, MeCP2, p16(INK4A), hMSH2 and c-myc were detected by using real-time PCR or RT-PCR. Promoter methylation of p16(INK4A), c-myc and hMSH2 genes was assayed by methylation-specific PCR (MSP) and sequencing (mapping). Their relationships were analyzed by Fisher's exact test using the software SPSS.
resultsThe average mRNA level of Dnmt1 gene from cancerous tissue was higher and that of mbd2 gene from cancerous tissue was lower than that from non-cancerous tissue, respectively. mbd2 was lower in cancerous tissue than in non-cancerous tissue in 14 (50.0%) of patients but higher in 3 cases (10.7%) of non-cancerous gastric tissue (P<0.001). c-myc expression was up-regulated in cancer tissues (P<0.05). The up-regulation of mbd2 was found in all patients with hypomethylated c-myc. The transcriptional levels of p16(INK4A) and MeCP2 genes did not display any difference between gastric cancerous and matched non-cancerous tissues. There were down-regulation and hypermethylation of hMSH2 in cancer tissues, and the hypermethylation of hMSH2 coexisted with down-regulated transcription. However, the transcription level of the above genes was not associated with biological behaviours of gastric cancers.
conclusionThe up-regulation of proto-oncogene may be the consequence of epigenetic control of gene expression by demethylase, and mbd2 is involved in the regulation of hMSH2 expression in human gastric cancer.
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