ArticleIntensive care medicine2005
Plasma volume measurement in septic patients using an albumin dilution technique: comparison with the standard radio-labelled albumin method.
Article in Intensive care medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Agreement Between Methods Assessing Changes in Plasma Volume During Fluid Therapy-A Post Hoc Analysis of a Randomized Trial.Acta anaesthesiologica Scandinavica · 2026Trial
- Albumin infusion rate and plasma volume expansion: a randomized clinical trial in postoperative patients after major surgery.Critical care (London, England) · 2019Trial
- Physiologically Motivated Sequential Population Modeling of Albumin Trends and Vedolizumab Pharmacokinetics for Pregnancy Dosing Regimen Optimization.Clinical pharmacology and therapeutics · 2026Article
- Estimating the plasma volume by infusing albumin: a retrospective feasibility study.Intensive care medicine experimental · 2025Article
- Blood volume in patients likely to be preload responsive: a post hoc analysis of a randomized controlled trial.Intensive care medicine experimental · 2023Article
- Beyond the fluid bolus.Journal of thoracic disease · 2019Article
- Effect of ringers acetate in different doses on plasma volume in rat models of hypovolemia.Intensive care medicine experimental · 2017Article
- A Survey of Pediatric Critical Care Providers on the Presence, Severity, and Assessment of Capillary Leak in Critically Ill Children.Journal of pediatric intensive care · 2017Article
- Isolated Brain Trauma in Cats Triggers Rapid Onset of Hypovolemia.Neurocritical care · 2017Article
- The effect of vitamin C on plasma volume in the early stage of sepsis in the rat.Intensive care medicine experimental · 2014Article
- A novel method for blood volume estimation using trivalent chromium in rabbit models.Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India · 2014Article
- In vivo multispectral photoacoustic and photothermal flow cytometry with multicolor dyes: a potential for real-time assessment of circulation, dye-cell interaction, and blood volume.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2011Article
- Anti-inflammatory effect of rosiglitazone is not reflected in expression of NFkappaB-related genes in peripheral blood mononuclear cells of patients with type 2 diabetes mellitus.BMC endocrine disorders · 2009Article
- Effect of blood pressure on plasma volume loss in the rat under increased permeability.Intensive care medicine · 2007Article
- Year in review in intensive care medicine, 2005. III. Nutrition, pediatric and neonatal critical care, and experimental.Intensive care medicine · 2006Review
- Comment on "Changes in acid-base balance following bolus infusion of 20% albumin solution in humans" by Bruegger et al.Intensive care medicine · 2006Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate a technique using 20% albumin for measurement of plasma volume in critically ill patients. DESIGN AND
settingLaboratory and clinical investigation in the adult intensive care unit and anaesthetic laboratories of a university hospital. PATIENTS: 12 patients fulfilling ACCP/SCCM criteria for septic shock. INTERVENTIONS AND MEASUREMENTS: Each patient received (125)I-labelled albumin, and the volume of distribution was measured at 1 and 10 min. The accepted standard plasma volume measurement (98% of the 10-min volume of distribution) was calculated. Immediately thereafter 200 ml 20% human albumin was given. Albumin concentrations were measured before and 1 min after this 40-g bolus, and the volume of distribution calculated using a formula that corrected for the 200 ml fluid in which the albumin was dissolved.
resultsPlasma volumes measured using the albumin dilution technique at 1 min were smaller than the standard technique by 110+/-280 ml; limits of agreement were from -660 to +440 ml (-16% to +11%). Plasma volumes measured by (125)I-albumin at 1 min were smaller than the standard by 120+/-110 ml; limits of agreement were from -330 to +100 ml (-8 to +2%).
conclusionsNon-labelled albumin can be used easily and quickly to measure a plasma volume in ICU patients and gives a moderately accurate estimate when compared with the (125)I-labelled albumin methods. The normal isotope method over-estimates plasma volumes in septic patients because excessive transcapillary escape of albumin is inadequately compensated for by the standard correction factor.
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