ArticlePLoS medicine2004
Assessment of volume depletion in children with malaria.
Article in PLoS medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Cardiovascular Findings in Severe Malaria: A Review.Global heart · 2020Pooled it
- Acceptability and efficacy of intra-rectal quinine alkaloids as a pre-transfer treatment of non-per os malaria in peripheral health care facilities in Mopti, Mali.Malaria journal · 2007Trial
- Cerebral Metabolic Crisis in Pediatric Cerebral Malaria.Journal of pediatric intensive care · 2023Article
- The Impact of Undernutrition on Cognition in Children with Severe Malaria and Community Children: A Prospective 2-Year Cohort Study.Journal of tropical pediatrics · 2021Article
- Observational
- Adjunctive therapy for severe malaria: a review and critical appraisal.Malaria journal · 2018Review
- Perspectives on aetiology, pathophysiology and management of shock in African children.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2017Review
- The role of previously unmeasured organic acids in the pathogenesis of severe malaria.Critical care (London, England) · 2015Article
- The pathogenesis of pediatric cerebral malaria: eye exams, autopsies, and neuroimaging.Annals of the New York Academy of Sciences · 2015Review
- Perioperative considerations of the patient with malaria.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2015Review
- The fluid management of adults with severe malaria.Critical care (London, England) · 2014Article
- Malaria biology and disease pathogenesis: insights for new treatments.Nature medicine · 2013Review
- Management of imported malaria in Europe.Malaria journal · 2012Review
- Medical research at the Albert Schweitzer Hospital.Wiener klinische Wochenschrift · 2010Article
- Antioxidant therapy: reducing malaria severity?Critical care medicine · 2009Article
- Hyponatremia in severe malaria: evidence for an appropriate anti-diuretic hormone response to hypovolemia.The American journal of tropical medicine and hygiene · 2009Article
- Malaria: progress, perils, and prospects for eradication.The Journal of clinical investigation · 2008Review
- Phase III trials required to resolve clinical equipoise over optimal fluid management in children with severe malaria.PLoS clinical trials · 2007Article
- Human malarial disease: a consequence of inflammatory cytokine release.Malaria journal · 2006Review
- Fluid resuscitation in malaria: the need for new randomised clinical trials.PLoS clinical trials · 2006Article
Corrections and comments
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Authors and funding
12 authors at 8 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe degree of volume depletion in severe malaria is currently unknown, although knowledge of fluid compartment volumes can guide therapy. To assist management of severely ill children, and to test the hypothesis that volume changes in fluid compartments reflect disease severity, we measured body compartment volumes in Gabonese children with malaria. METHODS AND
findingsTotal body water volume (TBW) and extracellular water volume (ECW) were estimated in children with severe or moderate malaria and in convalescence by tracer dilution with heavy water and bromide, respectively. Intracellular water volume (ICW) was derived from these parameters. Bioelectrical impedance analysis estimates of TBW and ECW were calibrated against dilution methods, and bioelectrical impedance analysis measurements were taken daily until discharge. Sixteen children had severe and 19 moderate malaria. Severe childhood malaria was associated with depletion of TBW (mean [SD] of 37 [33] ml/kg, or 6.7% [6.0%]) relative to measurement at discharge. This is defined as mild dehydration in other conditions. ECW measurements were normal on admission in children with severe malaria and did not rise in the first few days of admission. Volumes in different compartments (TBW, ECW, and ICW) were not related to hyperlactataemia or other clinical and laboratory markers of disease severity. Moderate malaria was not associated with a depletion of TBW.
conclusionsSignificant hypovolaemia does not exacerbate complications of severe or moderate malaria. As rapid rehydration of children with malaria may have risks, we suggest that fluid replacement regimens should aim to correct fluid losses over 12-24 h.
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