ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Target-dependent release of a presynaptic neuropeptide regulates the formation and maturation of specific synapses in Aplysia.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Neuronal sub-compartmentalization: a strategy to optimize neuronal function.Biological reviews of the Cambridge Philosophical Society · 2019Review
- Intra-axonal protein synthesis in development and beyond.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2016Review
- cJun and CREB2 in the postsynaptic neuron contribute to persistent long-term facilitation at a behaviorally relevant synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Asymmetric localization of natural antisense RNA of neuropeptide sensorin in Aplysia sensory neurons during aging and activity.Frontiers in genetics · 2014Article
- Molluscan cells in culture: primary cell cultures and cell lines.Canadian journal of zoology · 2013Article
- Persistent long-term synaptic plasticity requires activation of a new signaling pathway by additional stimuli.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- The nonsense-mediated decay pathway maintains synapse architecture and synaptic vesicle cycle efficacy.Journal of cell science · 2010Article
- Aplysia cell adhesion molecule and a novel protein kinase C activity in the postsynaptic neuron are required for presynaptic growth and initial formation of specific synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Article
- Postsynaptic regulation of long-term facilitation in Aplysia.Current biology : CB · 2008Article
- Cone and rod cells have different target preferences in vitro as revealed by optical tweezers.Molecular vision · 2008Article
- New tricks for an old slug: the critical role of postsynaptic mechanisms in learning and memory in Aplysia.Progress in brain research · 2008Review
- Multifunctional role of protein kinase C in regulating the formation and maturation of specific synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Local translation and directional steering in axons.The EMBO journal · 2007Review
- Protein kinase C regulates local synthesis and secretion of a neuropeptide required for activity-dependent long-term synaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Two mRNA-binding proteins regulate the distribution of syntaxin mRNA in Aplysia sensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Two signaling pathways regulate the expression and secretion of a neuropeptide required for long-term facilitation in Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Pyrene binary probes for unambiguous detection of mRNA using time-resolved fluorescence spectroscopy.Nucleic acids research · 2006Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The correct wiring of neurons is critical for the normal functioning of the nervous system. Sensory neurons of Aplysia form synapses with specific postsynaptic targets. Interaction with appropriate target cells in culture induces a significant increase in axon growth, the number of sensory neuron varicosities with release sites contacting the target, and regulates the expression and distribution of mRNAs encoding presynaptic proteins such as syntaxin and the sensory neuron-specific neuropeptide sensorin. Synapse stabilization is accompanied by the maintenance of presynaptic varicosities and target-dependent regulation of mRNA distributions. We report here that specific targets induce the release of sensorin from sensory neurons, which then regulates synaptic efficacy, axonal growth associated with synapse formation, the maintenance of synaptic contacts, and the specific distribution of mRNAs. Bath application of an antisensorin antibody during the early phase of synapse formation blocked the expected increase in synaptic strength, the growth and formation of new presynaptic varicosities, and the target-dependent regulation of mRNA distribution. In contrast, bath application of sensorin accelerated the increase in synaptic strength and enhanced the formation of new varicosities and target-dependent regulation of mRNA distribution in sensory neurons. As synapses stabilize, sensorin secretion declines but is required for the maintenance of synaptic efficacy, presynaptic varicosities, and mRNA distributions. These results suggest that a retrograde target signal regulates the secretion and actions of a presynaptic neuropeptide critical for the formation and maintenance of specific synapses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.