ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Activity affects dendritic shape and synapse elimination during steroid controlled dendritic retraction in Manduca sexta.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Neuronal excitability as a regulator of circuit remodeling.Current biology : CB · 2023Article
- Scrap and Build for Functional Neural Circuits: Spatiotemporal Regulation of Dendrite Degeneration and Regeneration in Neural Development and Disease.Frontiers in cellular neuroscience · 2020Review
- Sequential acquisition of cacophony calcium currents, sodium channels and voltage-dependent potassium currents affects spike shape and dendrite growth during postembryonic maturation of an identified Drosophila motoneuron.The European journal of neuroscience · 2014Article
- Dscam1 is required for normal dendrite growth and branching but not for dendritic spacing in Drosophila motoneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Putative excitatory and putative inhibitory inputs are localised in different dendritic domains in a Drosophila flight motoneuron.The European journal of neuroscience · 2013Article
- Temporal coherency between receptor expression, neural activity and AP-1-dependent transcription regulates Drosophila motoneuron dendrite development.Development (Cambridge, England) · 2013Article
- Drosophila as a model for MECP2 gain of function in neurons.PloS one · 2012Article
- Tiling among stereotyped dendritic branches in an identified Drosophila motoneuron.The Journal of comparative neurology · 2010Article
- Postembryonic development of centrally generated flight motor patterns in the hawkmoth, Manduca sexta.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2010Article
- Shaker and Shal mediate transient calcium-independent potassium current in a Drosophila flight motoneuron.Journal of neurophysiology · 2009Article
- PTX-induced hyperexcitability affects dendritic shape and GABAergic synapse density but not synapse distribution during Manduca postembryonic motoneuron development.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2009Article
- Metamorphosis of an identified serotonergic neuron in the Drosophila olfactory system.Neural development · 2007Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insect metamorphosis is a compelling example for dendritic and synaptic remodeling as larval and adult behaviors place distinct demands on the CNS. During the metamorphosis of the moth, Manduca sexta, many larval motoneurons are remodeled to serve a new function in the adult. During late larval life, steroid hormones trigger axonal and dendritic regression as well as larval synapse elimination. These regressive events are accompanied by stereotypical changes in motor behavior during the so-called wandering stages. Both normally occurring changes in dendritic shape and in motor output have previously been analyzed quantitatively for the individually identified motoneuron MN5. This study tested whether activity affected steroid-induced dendritic regression and synapse disassembly in MN5 by means of chronically implanted extracellular electrodes. Stimulating MN5 in vivo in intact, normally developing animals during a developmental period when it usually shows no activity significantly slowed the regression of high-order dendrites. Both physiological and anatomical analysis demonstrated that reduced dendritic regression was accompanied by a significant reduction in larval synapse disassembly. Therefore, steroid-induced alterations of dendritic shape and synaptic connectivity are modified by activity-dependent mechanisms. This interaction might be a common mechanism for rapid adjustments of rigid, inflexible, hormonal programs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.