ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
The S6KII (rsk) gene of Drosophila melanogaster differentially affects an operant and a classical learning task.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 78 citations in OpenAlex.
- Shaping of olfactory responses by taste in a new assay for operant learning in Drosophila melanogaster.The Journal of experimental biology · 2025Article
- RSK1 and RSK2 as therapeutic targets: an up-to-date snapshot of emerging data.Expert opinion on therapeutic targets · 2024Review
- On the origin of appetite: GLWamide in jellyfish represents an ancestral satiety neuropeptide.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Engineered microRNA-based regulatory element permits safe high-dose miniMECP2 gene therapy in Rett mice.Brain : a journal of neurology · 2021Article
- Cellular and circuit mechanisms of olfactory associative learning inJournal of neurogenetics · 2020Review
- A kinase-dependent feedforward loop affects CREBB stability and long term memory formation.eLife · 2018Article
- Animal Models for Coffin-Lowry Syndrome: RSK2 and Nervous System Dysfunction.Frontiers in behavioral neuroscience · 2018Review
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- The Drosophila melanogaster tribbles pseudokinase is necessary for proper memory formation.Neurobiology of learning and memory · 2017Article
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- Loss of the Coffin-Lowry syndrome-associated gene RSK2 alters ERK activity, synaptic function and axonal transport in Drosophila motoneurons.Disease models & mechanisms · 2015Article
- Outcome learning, outcome expectations, and intentionality in Drosophila.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Review
- Effect of circadian phase on memory acquisition and recall: operant conditioning vs. classical conditioning.PloS one · 2013Article
- The visual orientation memory of Drosophila requires Foraging (PKG) upstream of Ignorant (RSK2) in ring neurons of the central complex.Learning & memory (Cold Spring Harbor, N.Y.) · 2012Article
- The C-terminal kinase and ERK-binding domains of Drosophila S6KII (RSK) are required for phosphorylation of the protein and modulation of circadian behavior.The Journal of biological chemistry · 2012Article
- Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases.Microbiology and molecular biology reviews : MMBR · 2011Review
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- Coffin-Lowry syndrome.European journal of human genetics : EJHG · 2010Review
- Short-term memories in Drosophila are governed by general and specific genetic systems.Learning & memory (Cold Spring Harbor, N.Y.) · 2010Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
In an attempt to dissect classical and operant conditioning in Drosophila melanogaster, we have isolated the gene for ribosomal S6 kinase II (S6KII). This enzyme is part of a family of serine-threonine kinases that in mammals have been implicated in the MAPK (mitogen-activated protein kinase) signaling cascade controlling (among other processes) synaptic plasticity (long-term potentiation/long-term depression) and memory formation. The human homolog rsk2 has been linked to mental retardation (Coffin-Lowry syndrome). Mutant analysis in Drosophila shows that S6KII serves different functions in operant place learning and classical (pavlovian) olfactory conditioning. Whereas in the null mutant only pavlovian olfactory learning is affected, a P-element insertion mutant reducing the amount of S6KII only affects operant place learning. A mutant lacking part of the N-terminal kinase domain and performing poorly in both learning tasks is dominant in the operant paradigm and recessive in the pavlovian paradigm. The behavioral defects in the pavlovian task can be rescued by the genomic S6KII transgene. Overexpression of S6KII in wild type has a dominant-negative effect on the operant task that is rescued by the null mutant, whereas in the pavlovian task overexpression may even enhance learning performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.