ReviewThe Lancet. Infectious diseases2004
The aetiology, origins, and diagnosis of severe acute respiratory syndrome.
Review in The Lancet. Infectious diseases, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
96 citing papers in PubMed, 1 synthesis or guideline pooled it, 185 citations in OpenAlex.
- The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis.Scientific reports · 2015Pooled it
- Alpha- and Beta-Coronaviruses in Humans and Animals: Taxonomy, Reservoirs, Hosts, and Interspecies Transmission.Microorganisms · 2025Review
- Bat Ecology and Microbiome of the Gut: A Narrative Review of Associated Potentials in Emerging and Zoonotic Diseases.Animals : an open access journal from MDPI · 2024Review
- The immunomodulatory properties of low-level ionizing radiation as a potential treatment for COVID-19's life-threatening symptoms.European journal of medical research · 2023Review
- Sewage surveillance system using urological wastewater: Key to COVID-19 monitoring?Urologic oncology · 2023Review
- Short-, Mid-, and Long-Term Epidemiological and Economic Effects of the World Bank Loan Project on Schistosomiasis Control in the People's Republic of China.Diseases (Basel, Switzerland) · 2022Article
- Review
- Revising the paradigm: Are bats really pathogen reservoirs or do they possess an efficient immune system?iScience · 2022Review
- Activity of a Carbohydrate-Binding Module Therapy, Neumifil, against SARS-CoV-2 Disease in a Hamster Model of Infection.Viruses · 2022Article
- COVID-19: why not learn from the past?Frontiers of medicine · 2021Article
- COVID-19 among Health Workers in Germany-An Update.International journal of environmental research and public health · 2021Article
- Update on Potentially Zoonotic Viruses of European Bats.Vaccines · 2021Review
- Airborne Coronaviruses: Observations from Veterinary Experience.Pathogens (Basel, Switzerland) · 2021Review
- Digestive system involvement of infections with SARS-CoV-2 and other coronaviruses: Clinical manifestations and potential mechanisms.World journal of gastroenterology · 2021Review
- Neurologic Manifestations of the World Health Organization's List of Pandemic and Epidemic Diseases.Frontiers in neurology · 2021Review
- Human Coronavirus Infections and Pregnancy.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2021Review
- The SARS-CoV-2 outbreak from a one health perspective.One health (Amsterdam, Netherlands) · 2020Article
- Laboratory diagnosis of novel corona virus (2019-nCoV)-present and the future.The Indian journal of tuberculosis · 2020Review
- High anal swab viral load predisposes adverse clinical outcomes in severe COVID-19 patients.Emerging microbes & infections · 2020Article
- A nursing informatics response to COVID-19: Perspectives from five regions of the world.Journal of advanced nursing · 2020Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Severe acute respiratory syndrome (SARS) is a new infectious disease that first emerged in Guangdong province, China, in November, 2002. A novel coronavirus was later identified in patients with SARS. The detection of the virus in these patients, its absence in healthy controls or other patients with atypical pneumonia, and the reproduction of a similar disease in a relevant animal model fulfilled Koch's postulates for implicating this coronavirus as the causal agent of SARS. The full genome sequence was determined within weeks of the virus's identification. The rapid progress in the aetiology, the development of laboratory diagnostic tests, and the defining of routes of viral transmission were facilitated through a unique WHO-coordinated virtual network of laboratories, which shared information on a real-time basis through daily teleconferences. Subsequent studies have indicated that the SARS coronavirus is of animal origin, that its precursor is still present in animal populations within the region, and that live-animal markets in southern China may have provided the animal-human interphase that allowed this precursor virus to adapt to human-human transmission. These findings underscore the potential for the re-emergence of SARS and the need for laboratory tests for early diagnosis. However, the low viral load in the respiratory tract makes early diagnosis of SARS a diagnostic challenge, although improvements in the sensitivity of molecular diagnostic methods continue to be made.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.