Evidence map›Paper›PMID 15522362›Full record

Trial reportOphthalmology2004

Surgery for subfoveal choroidal neovascularization in age-related macular degeneration: ophthalmic findings: SST report no. 11.

Barbara S Hawkins, Neil M Bressler, Päivi H Miskala, Susan B Bressler, Nancy M Holekamp, Marta J Marsh, Maryann Redford, Steven D Schwartz, Paul Sternberg, Matthew A Thomas and 2 more

Open access · greenAbstract readClinical TrialMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Ophthalmology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 6 pooled it
22.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 6 syntheses or guidelines pooled it, 161 citations in OpenAlex.

  1. Surgery for postvitrectomy cataract.The Cochrane database of systematic reviews · 2018
    Pooled it
  2. Surgery for post-vitrectomy cataract.The Cochrane database of systematic reviews · 2013
    Pooled it
  3. Surgery for post-vitrectomy cataract.The Cochrane database of systematic reviews · 2008
    Pooled it
  4. Laser photocoagulation for neovascular age-related macular degeneration.The Cochrane database of systematic reviews · 2007
    Pooled it
  5. Age related macular degeneration.BMJ clinical evidence · 2007
    Pooled it
  6. The end of submacular surgery for age-related macular degeneration? A meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2007
    Pooled it
  7. Trial
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  13. Article
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  17. Review
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  19. Visual function quality of life measure changes upon conversion to neovascular age-related macular degeneration in second eyes.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2017
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Barbara S HawkinsSST Coordinating Center, Wilmer Clinical Trials and Biometry, 550 North Broadway, 9th Floor, Baltimore, MD 21205-2010, USA. bhawkins@jhmi.edu
Neil M Bressler
Päivi H Miskala
Susan B Bressler
Nancy M Holekamp
Marta J Marsh
Maryann Redford
Steven D Schwartz
Paul Sternberg
Matthew A Thomas
David J Wilson
Submacular Surgery Trials (SST) Research Group
Zimmer Biomet (United States) · US

Funding

SUBMACULAR SURGERY TRIALS--STUDY CHAIRMANS OFFICE GRANTU10EY011547 · NEI · JOHNS HOPKINS UNIVERSITY · PI BRESSLER, NEIL M · 1996 to 2005
$8.1M
SUBMACULAR SURGERY TRIALS--COORDINATING CENTERU10EY011557 · NEI · JOHNS HOPKINS UNIVERSITY · PI HAWKINS, BARBARA SNYDER · 1997 to 2004
$4.6M
SUBMACULAR SURGERY TRIALS--PHOTOGRAPH READING CENTERU10EY011558 · NEI · JOHNS HOPKINS UNIVERSITY · PI BRESSLER, SUSAN B · 1997 to 2003
$1.4M
NEI NIH HHS EY11557NEI NIH HHS EY11558NEI NIH HHS U10 EY011547NEI NIH HHS U10 EY011547-07NEI NIH HHS U10 EY011557NEI NIH HHS U10 EY011557-08NEI NIH HHS U10 EY011558NEI NIH HHS U10 EY011558-07NEI NIH HHS U10 EY11547
6 · The paper itself

Abstract

purposeTo present visual acuity (VA) and related findings from patients enrolled in one of the Submacular Surgery Trials (SST) evaluating surgical removal versus observation of subfoveal choroidal neovascularization secondary to age-related macular degeneration (SST Group N Trial).

designRandomized clinical trial.

participantsEligible patients had age-related macular degeneration with subfoveal choroidal neovascularization, some with a classic pattern on fluorescein angiography, and best-corrected VA (BCVA) of 20/100 to 20/800 in one eye (study eye) that had received no treatment in the macula. Any contiguous blood had to account for <50% of the total area occupied by the subfoveal lesion (maximum size, 9.0 disc areas [22.9 mm2]).

methodsRandomization was stratified by VA and by clinical center. All patients were scheduled for study examinations at 3, 6, 12, and 24 months after enrollment for assessment of study outcomes.

main outcome measureA successful outcome was defined a priori to be either improvement of BCVA or VA no more than 1 line (7 letters) worse than baseline at the 24-month examination.

resultsOf 454 patients enrolled, 228 study eyes were assigned to observation and 226 to surgery. The percentages of eyes that had successful outcomes were similar in the 2 arms: 44% assigned to observation and 41% assigned to surgery. Median VA losses from baseline to the 24-month examination were 2.1 lines (10.5 letters) in the observation arm and 2.0 lines (10 letters) in the surgery arm. Median VA declined from 20/100 at baseline to 20/400 at 24 months in both arms. No subgroup of patients was identified in which submacular surgery led to better VA outcomes. In the surgery arm, 55 (39%) of 142 initially phakic eyes had cataract surgery by the 24-month examination, compared with 6 (5%) of 133 eyes in the observation arm. Rhegmatogenous retinal detachment occurred in 12 surgery eyes (5%) and 1 observation eye.

conclusionsSubmacular surgery, as performed in this clinical trial, did not improve or preserve VA for 24 months in more eyes than observation and is not recommended for patients with similar lesions. This article contains additional online-only material available at http://www.ophsource.com/periodicals/ophtha.

Indexed as

AgedAged, 80 and overChoroidal NeovascularizationContrast SensitivityFemaleFluorescein AngiographyFovea CentralisHumansIntraoperative ComplicationsMacular DegenerationMaleMiddle AgedNational Institutes of Health (U.S.)Ophthalmologic Surgical ProceduresReadingTreatment Outcome

Identifiers

PMID15522362
PMCPMC1256024
OpenAlexW150210721

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.