ArticleBritish journal of clinical pharmacology2004
Association between adherence to statin therapy and lipid control in Hong Kong Chinese patients at high risk of coronary heart disease.
Article in British journal of clinical pharmacology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Interventions to improve adherence to lipid-lowering medication.The Cochrane database of systematic reviews · 2016Pooled it
- Length of time periods in treatment effect descriptions and willingness to initiate preventive therapy: a randomised survey experiment.BMC medical informatics and decision making · 2018Trial
- A simple informative intervention in primary care increases statin adherence.European journal of clinical pharmacology · 2016 · on this mapTrial
- Effect of a medication-taking behavior feedback theory-based intervention on outcomes in patients with heart failure.Journal of cardiac failure · 2012Trial
- [Therapy compliance in cases of hyperlipaemia, as measured through electronic monitors. Is a reminder calendar to avoid forgetfulness effective?].Atencion primaria · 2007Trial
- Factors Affecting Adherence to Lipid-lowering Drugs: A Scoping Review.Oman medical journal · 2023Article
- Patient-centered mobile health technology intervention to improve self-care in patients with chronic heart failure: Protocol for a feasibility randomized controlled trial.Contemporary clinical trials · 2021Article
- Living environment, social support, and informal caregiving are associated with healthcare seeking behaviour and adherence to medication treatment: A cross-sectional population study.Health & social care in the community · 2019Article
- A Metaanalysis of Interventions to Improve Adherence to Lipid-Lowering Medication.Ochsner journal · 2016Review
- Patterns of Non-adherence to Supplementation with Calcium and Vitamin D in Persistent Postmenopausal Women Are Similar at Start and 1 Year Later: A Qualitative Longitudinal Study.Frontiers in pharmacology · 2016Article
- Factors associated with medical orders' compliance among hyperlipidemic patients.Iranian journal of nursing and midwifery research · 2013Article
- Lipid control and use of lipid-regulating drugs for prevention of cardiovascular events in Chinese type 2 diabetic patients: a prospective cohort study.Cardiovascular diabetology · 2010Article
- Facilitating Clinical Research through the Health Information Exchange: Lipid Control as an Example.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2010Article
- Medication adherence is a mediator of the relationship between ethnicity and event-free survival in patients with heart failure.Journal of cardiac failure · 2010Article
- The gender differences in baseline characteristics and statin intervention among outpatients with coronary heart disease in China: the China Cholesterol Education Program.Clinical cardiology · 2009Article
- Predictors of medication adherence using a multidimensional adherence model in patients with heart failure.Journal of cardiac failure · 2008Article
- Cancer and cholesterol: understanding the V-shaped association in patients with diabetes.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2008Review
- Objectively measured, but not self-reported, medication adherence independently predicts event-free survival in patients with heart failure.Journal of cardiac failure · 2008Article
- The significance of compliance and persistence in the treatment of diabetes, hypertension and dyslipidaemia: a review.International journal of clinical practice · 2008Review
- Modeling and simulation of adherence: approaches and applications in therapeutics.The AAPS journal · 2005Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo examine the pattern of adherence to statin therapy and to determine the association of adherence to statin therapy and the control of serum low-density lipoprotein (LDL)-cholesterol in a cohort of Hong Kong Chinese patients at high risk of coronary heart disease (CHD).
methodsThis was a prospective observational cohort study conducted at the outpatient clinics of a public teaching hospital in Hong Kong. Patients at high risk of CHD who had been initiated on statin monotherapy for < 12 months were recruited. The statin prescription was dispensed in a bottle with the Medication Event Monitoring System (MEMS). Adherence was assessed in two dimensions: dose-count was defined as the percentage of doses taken, and dose-time was defined as the percentage of doses taken within the suggested time interval. Lipid profiles were obtained at baseline and during two follow-up visits at month 3 and month 6.
resultsEighty-three patients completed the study. The median adherence to dose-count and to dose-time were 95% (25-75th percentile = 87-99%) and 78% (25-75th percentile = 17-92%), respectively. Both dose-count and dose-time adherence declined slightly over the first 6 months of therapy. Living with family [relative risk (RR) = 0.79, 95% confidence interval (CI) 0.63, 0.91] and duration of therapy (RR = 0.99, 95% CI 0.98, 1.00) were negative predictors while number of family members (among those living with family) (RR = 1.05, 95% CI 1.00, 1.08) was a positive predictor for adherence to dose-count. Monthly household income (RR = 1.01, 95% CI 1.00, 1.02) and angina (RR = 1.29, 95% CI 1.05, 1.58) were positive predictors while living with family (RR = 0.74, 95% CI 0.55, 0.90) was a negative predictor for dose-time adherence. Percent reduction in serum LDL-cholesterol was correlated to dose-count (P < 0.001) and dose-time (P = 0.047) adherence. Statistically significant correlations were observed between adherence to dose-count and LDL reduction (R(2) = 0.130; P = 0.001), and between dose-time adherence and LDL reduction (R(2) = 0.048; P = 0.047).
conclusionHigh adherence to statin therapy was found in a cohort of Chinese patients at high risk of CHD and the adherence declined slightly over time. A weak association between adherence to statin dose-count and LDL reduction and a marginal association between dose-time adherence and LDL reduction were observed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.