Drug development and use in the elderly: search for the right dose and dosing regimen (Parts I and II).

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

1. Cardiovascular drug therapy in elderly patients: specific age-related pharmacokinetic, pharmacodynamic and therapeutic considerations.Drugs & aging · 2005
   Pooled it
2. Nomograms based on clinical factors to predict abnormal metabolism of psychotropic drugs.Biomedical reports · 2025
   Article
3. La Tunisie medicale · 2024
   Article
4. Impact of medicine shortages on patients - a framework and application in the Netherlands.BMC health services research · 2022
   Article
5. Profiling the most elderly parkinson's disease patients: Does age or disease duration matter?PloS one · 2021
   Article
6. Primary care physician's approach for mental health impact of COVID-19.Journal of family medicine and primary care · 2020
   Review
7. Sedation with dexmedetomidine in elderly patients during dental surgery: a retrospective case series.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2019
   Article
8. Influence of age and renal impairment on the steady state pharmacokinetics of filgotinib, a selective JAK1 inhibitor.British journal of clinical pharmacology · 2018
   Article
9. Comparison between the Effect of Cow Ghee and Butter on Memory and Lipid Profile of Wistar Rats.Journal of clinical and diagnostic research : JCDR · 2016
   Article
10. Drug Utilization and Inappropriate Prescribing in Centenarians.Journal of the American Geriatrics Society · 2016
    Article
11. Effect of age on drug metabolism in women with breast cancer.Expert opinion on drug metabolism & toxicology · 2015
    Review
12. Use of potentially inappropriate medicines in elderly: A prospective study in medicine out-patient department of a tertiary care teaching hospital.Indian journal of pharmacology · 2010
    Article
13. To scale or not to scale: the principles of dose extrapolation.British journal of pharmacology · 2009
    Review
14. Predicting the clinical relevance of drug interactions from pre-approval studies.Drug safety · 2009
    Review
15. Potential prescription patterns and errors in elderly adult patients attending public primary health care centers in Mexico City.Clinical interventions in aging · 2009
    Article
16. The elderly--a challenge for appropriate drug treatment.European journal of clinical pharmacology · 2008
    Article
17. Clinical pharmacology of cancer therapies in older adults.British journal of cancer · 2008
    Review
18. The clinical implications of ageing for rational drug therapy.European journal of clinical pharmacology · 2008
    Review
19. A composite screening tool for medication reviews of outpatients: general issues with specific examples.Drugs & aging · 2007
    Review
20. Drug dosage in the elderly: dermatological drugs.Drugs & aging · 2006
    Review

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as