ArticleMammalian genome : official journal of the International Mammalian Genome Society2004
Bovine beta-defensins: identification and characterization of novel bovine beta-defensin genes and their expression in mammary gland tissue.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 79 citations in OpenAlex.
- Immunomodulatory activities of bovine host defense peptides (HDPs): context-dependent roles in inflammation and immune priming.BMC veterinary research · 2026Article
- The effect of staphylococcal infection on cathelicidin and β-defensin mRNA levels in epithelial cells lining the mammary gland cistern.Frontiers in immunology · 2026Article
- Alterations in Whey Protein Abundance Correlated with the Somatic Cell Count Identified via Label-Free and Selected Reaction Monitoring Proteomic Approaches.Animals : an open access journal from MDPI · 2025Article
- β-Defensin gene copy number variation in cattle.Royal Society open science · 2024Article
- Expression, Regulation, and Function of β-Defensins in the Bovine Mammary Glands: Current Knowledge and Future Perspectives.Animals : an open access journal from MDPI · 2023Review
- Evolutionary trend of bovine β-defensin proteins toward functionality prediction: A domain-based bioinformatics study.Heliyon · 2023Article
- Effect of Supplementation with Organic Selenium or Turmeric and Rosemary Mixture on Beta-Defensin Content in Goat Milk.Animals : an open access journal from MDPI · 2022Article
- Molecular Identification and Antibacterial Activity Analysis of Blue Fox (Animals : an open access journal from MDPI · 2021Article
- NETosis of Peripheral Neutrophils Isolated From Dairy Cows Fed Olive Pomace.Frontiers in veterinary science · 2021Article
- Associations between Bovine β-Defensin 4 Genotypes and Production Traits of Polish Holstein-Friesian Dairy Cattle.Animals : an open access journal from MDPI · 2019Article
- Diversifying selection signatures among divergently selected subpopulations of Polish Red cattle.Journal of applied genetics · 2019Article
- Sensing of Escherichia coli and LPS by mammary epithelial cells is modulated by O-antigen chain and CD14.PloS one · 2018Article
- β-Defensins: Farming the Microbiome for Homeostasis and Health.Frontiers in immunology · 2018Review
- β-defensins: An innate defense for bovine mastitis.Veterinary world · 2017Review
- Rumen-derived lipopolysaccharide enhances the expression of lingual antimicrobial peptide in mammary glands of dairy cows fed a high-concentrate diet.BMC veterinary research · 2016Article
- Expression patterns of β-defensin and cathelicidin genes in parenchyma of bovine mammary gland infected with coagulase-positive or coagulase-negative Staphylococci.BMC veterinary research · 2014Article
- Article
- Polymorphisms of β-defensin genes in Valle del Belice dairy sheep.Molecular biology reports · 2011Article
- The role of oct-1 in the regulation of tracheal antimicrobial peptide (TAP) and lingual antimicrobial peptide (LAP) expression in bovine mammary epithelial cells.Immunogenetics · 2011Article
- Molecular analysis and recombinant expression of bovine neutrophil β-defensin 12 and its antimicrobial activity.Molecular biology reports · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
beta-Defensin genes code for multifunctional peptides with a broad-range antimicrobial activity. In this project we hypothesized that beta-defensin genes may be candidate genes for resistance to mastitis. In this article we describe the identification and genomic characterization of eight bovine beta-defensin genes, including six novel defensin genes and two pseudogenes. Expression in the bovine mammary gland of one of the novel genes, DEFB401, has been demonstrated, as well as the expression of LAP, TAP, DEFB1, BNBD3, BNBD9, and BNBD12. For genomic characterization, 20 BACs from two different bovine BAC libraries (RZPD numbers 750 and 754) were isolated by PCR screening with beta-defensin consensus primers derived from published sequences. PCR products from BACs generated with consensus primers have been subcloned and sequenced, revealing a total of 16 genes and two pseudogenes. Six novel beta-defensin genes share the typical exon-intron structure and are highly homologous to published bovine beta-defensin genes. They are named DEFB401- DEFB405 and LAP-like, and two novel pseudogenes are named EBD-P and EBD-P2. Analysis of mammary gland tissue-derived cDNA from nine cows with different clinical findings demonstrated the expression of several beta-defensin genes mentioned above. First results indicate that the lactational status of the cow presumably has no influence on gene expression. Competent knowledge of antimicrobial activity of beta-defensins from literature, the abundance of beta-defensin mRNA in the bovine mammary gland, and the inducibility of some genes give first evidence that beta-defensins may play a role in local host defense during udder infections.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.