ArticleMammalian genome : official journal of the International Mammalian Genome Society2004
Quantitative trait loci for steady-state platelet count in mice.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Genome-wide association study identifies candidate Loci associated with platelet count in koreans.Genomics & informatics · 2014Article
- Genetic analysis of hematological parameters in incipient lines of the collaborative cross.G3 (Bethesda, Md.) · 2012Article
- The genetics of common variation affecting platelet development, function and pharmaceutical targeting.Journal of thrombosis and haemostasis : JTH · 2011Review
- Determinants of platelet count in humans.Haematologica · 2011Article
- Article
- Detection of quantitative trait loci affecting haematological traits in swine via genome scanning.BMC genetics · 2010Article
- Article
- Quantitative trait loci for peripheral blood cell counts: a study in baboons.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- Evolutionary conservation of metabolism explains howDrosophila nutrigenomics can help us understand human nutrigenomics.Genes & nutrition · 2006Article
- Quantitative trait loci for baseline erythroid traits.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
- Quantitative trait loci for baseline white blood cell count, platelet count, and mean platelet volume.Mammalian genome : official journal of the International Mammalian Genome Society · 2005Article
- Development of a highly fecund inbred strain of mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Platelet count in humans is a strongly genetically regulated trait, with approximately 85% of the interindividual variance in platelet numbers attributable to genetic factors. Inbred mouse strains also have strain-specific platelet count ranges. As part of a project to identify novel factors that regulate platelet count, we identified two inbred mouse strains, CBA/CaH and QSi5, with substantial differences in platelet count (mean values of 581 vs. 1062 x 10(9)/L). An F(2) intercross resource of 1126 animals was bred from these two parental strains for a genomewide scan for quantitative trait loci (QTL) for platelet count. QTL were identified on MMU1 (LOD 6.8, p < 0.0005) and MMU11 (LOD 11.2, p < 0.0005) by selectively genotyping animals from the extremes of the F(2) platelet count distribution. Three other QTL of suggestive statistical significance were also detected on MMU7, 13, and 17. It is noteworthy that no QTL were detected in the vicinity of the genes encoding thrombopoietin ( Thpo), and its receptor ( c-Mpl), both known to influence platelet production. Comparison of gene expression levels between the parental mouse strains by microarrays also showed little difference in the mRNA levels of these known candidate genes. These results represent the first published use of a genetic linkage-based approach in a mouse model toward the identification of genetic factors that regulate platelet count.
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