ArticleMammalian genome : official journal of the International Mammalian Genome Society2004
The Tyr (albino) locus of the laboratory mouse.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Effect of Short Tandem Target Mimic miR-5110 on Melanogenesis in Melanocytes of Alpaca (Current issues in molecular biology · 2026Article
- A Narrowband 635 nm Autofluorescence Peak in Albino Mouse Eyes Found With Multi-Modal Imaging Reveals the Presence of Protoporphyrin IX in the Choroid.Investigative ophthalmology & visual science · 2025Article
- A Comparative Study on the Sensitivity of Establishing Melasma-Like Models in Different Strains of Mice.Journal of cosmetic dermatology · 2025Article
- Article
- Human equivalent doses of L-DOPA rescues retinal morphology and visual function in a murine model of albinism.Scientific reports · 2023Article
- Whole-exome sequencing prioritizes candidate genes for hereditary cataract in the Emory mouse mutant.G3 (Bethesda, Md.) · 2023Article
- Ghost rodents: Albinism in Australian rodent species.Ecology and evolution · 2023Article
- PMEL p.Leu18del dilutes coat color of Kumamoto sub-breed of Japanese Brown cattle.BMC genomics · 2022Article
- Albino mice with the point mutation at the tyrosinase locus show high cholesterol diet-induced NASH susceptibility.Scientific reports · 2021Article
- Article
- A method for CRISPR/Cas9 mutation of genes in fathead minnow (Pimephales promelas).Aquatic toxicology (Amsterdam, Netherlands) · 2020Article
- Insights into the genetic basis of retinal detachment.Human molecular genetics · 2020Article
- A genome-wide scan study identifies a single nucleotide substitution in the tyrosinase gene associated with white coat colour in a red deer (Cervus elaphus) population.BMC genetics · 2020Article
- Article
- Cdrom Archive: A Gateway to Study Camel Phenotypes.Frontiers in genetics · 2019Review
- CRISPR/Cas9-mediated mutation of tyrosinase (Tyr) 3' UTR induce graying in rabbit.Scientific reports · 2017Article
- Development of Neurological Mouse Model for Toxoplasmosis UsingPathology research international · 2017Article
- Transcriptome analysis reveals the potential mechanism of the albino skin development in pufferfish Takifugu obscurus.In vitro cellular & developmental biology. Animal · 2015Article
- Tyrosinase Depletion Prevents the Maturation of Melanosomes in the Mouse Hair Follicle.PloS one · 2015Article
- The albino mutation of tyrosinase alters ocular angiogenic responsiveness.Angiogenesis · 2013Article
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Authors and funding
3 authors.
Funding
Abstract
The albino mouse was already known in ancient times and was apparently selectively bred in Egypt, China, and Japan. Thus, it is not surprising that the c or albino locus (now the Tyr locus) was among the first used to demonstrate Mendelian inheritance in mammals at the dawn of the past century. This locus is now known to encode tyrosinase, the rate-limiting enzyme in the production of melanin pigment, and the molecular basis of the albino ( Tyr(c)) mutation is known. Here we describe the congenic series of Tyr-locus alleles, from wild type to null ( albino). We compare eye and skin pigmentation phenotypes and the genetic lesions that cause each. We suggest that this panel of congenic mutants contains rich, untapped resources for the study of many questions of basic cell biological interest.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.